Sr. Staff to Sr. Research Scientist (Immunology/Biotherapeutics) - United States
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The individual will work in a highly interactive organization and be part of immune-oncology team focusing on in vitro target validation for biotherapeutics. The successful candidate will be able to utilize the appropriate in vitro cell-based models to explore/validate the biology of novel antibody-based immune-oncology targets in early discovery programs. The candidate should also have experience in developing in vitro assays and a sound knowledge of technologies commonly used to assess immune endpoints.
Summary of the Essential Functions of the Job
- Establish and execute in vitro experiments to determine the functional effect(s) of candidate target activation/inhibition by using a variety of assays to interrogate immune end-points
- Cell isolation using magnetic bead-based or flow cytometry-based methods
- Measure mRNA levels, proteins, cytokines and tissue-specific markers in cell lines, tissue culture supernatants, biological fluids and tissues by quantitative RT-PCR, western blot, ELISA, and flow cytometry
- Effectively communicate and present scientific data
- Data analysis, excellent notebook keeping, and familiarity with data retrieval and input from a database.
- Must be able to perform in a fast paced environment and deliver high quality data in a timely manner
- B.S. or M.S. in Immunology, Cancer Biology, Pharmacology or related field
- Pharmaceutical or biotech experience preferred, but not required
- Experience with immunology, molecular and cell biology techniques (e.g. flow cytometry, ELISA, pPCR, western blot)
- Excellent oral and written communication skills, proven ability to multi-task, and works well independently or in a team environment.