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Sr. Staff Scientist, Pharmacology (non-oncology unit) Wilmington United States,  

Incyte (company)


Posted on : 01 May 2017

Project Description

                                  

Job Summary

Building upon Incyte’s successful oncology pipeline, we are now expanding the Pharmacology group into non-oncology disease indications. The successful candidate would be responsible for designing and executing studies for novel target identification and efficacy evaluation of potential first-in-class / best-in-class compounds. The candidate will work in a highly interactive environment including close collaborations with representatives from other departments in the organization.

The position is responsible for in vitro and in vivo pharmacological evaluation of compounds using cell based assays and preclinical models.  

Summary of the Essential Functions of the Job

  • Cell culture, in vitro cell-based target modulation and functional assays (cell cycle, apoptosis, proliferation etc.) using primary cells and/or established cell lines.
  • Isolation of proteins, DNA, RNA from primary cells, cell lines and tissues.
  • Experience with quantitative RT-PCR, western blot, ELISA and flow cytometry.
  • Identification/validation of novel targets by CRISPR, siRNA and shRNA in cell lines.
  • Utilize innovative preclinical in vivo study designs incorporating efficacy, pharmacodynamic and pharmacokinetic readouts to answer key biological or pharmacological questions.
  • Data analysis, excellent notebook keeping, and familiarity with data retrieval and input from and into a database.
  • Effectively communicate and present scientific data.

Minimum Requirements

  • BS in Biology/Pharmacology with 2 years minimum drug discovery experience.
  • Experience with in vivo models of inflammatory, metabolic or genetic diseases.
  • Expertise in the application of cell culture, flow cytometry, functional and molecular assays essential.
  • Excellent computer and data analysis skills.
  • The successful candidate must have good communication skills, and be able to work productively in a dynamic environment in a team as well as independently.

 

Locations

Wilmington DE

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