Sr. Assoc. Scientist, Biology Cambridge United States,
Celgene is a global biopharmaceutical company leading the way in medical innovation to help patients live longer, better lives. Our purpose as a company is to discover and develop therapies that will change the course of human health. We value our passion for patients, quest for innovation, spirit of independence and love of challenge. With a presence in more than 70 countries, and growing - we look for talented people to grow our business, advance our science and contribute to our unique culture.
The Immunology& Inflammation Late Discovery Biology group is seeking a self-motivated, energetic, detail-oriented candidate with strong background in cellular immunology and molecular biology. The primary focus of this position will be to develop and perform a variety of in vitro assays, with human or animal primary immune cells, to evaluate novel small molecules for drug candidate screening, lead optimization, and mechanism of action. The individual will participate in a broad range of programs in a dynamic, small research group and be comfortable working in a fast paced environment. Strong problem solving and time management skills are essential to complete diverse assigned tasks. Industry experience is preferred.
Responsibilities will include, but are not limited to, the following:
Design, plan, and execute cell based assays and troubleshoot existing protocols with guidance Perform high quality and well controlled immunological assays with human and animal primary immune cells including cell stimulation, cytokine analysis, and flow cytometry with minimal supervision Support scientists in execution of proof-of-concept studies. Generate and independently analyze multi-parameters data sets using appropriate analytic programs Maintain well written and accurate research electronic notebook detailing work undertaken Comply with laboratory safety procedures
Extensive experience in isolation, culture, and characterization of primary immune cells from human and animal tissues Strong hands-on experience with common immunological assays (cell activation, proliferation assays, cytokine analysis by FACS and ELISA, and multiplex assays) Experience with lymphocyte and myeloid cell activation and characterization assays, multi-parameter flow cytometry, ELISA, ELISpot, RT-PCR, RNA preparation, viral transduction, mammalian cell transfection, immunoprecipitation, and western blotting. Proficiency with FlowJo, Prism, and Microsoft office applications Possess a thorough knowledge of experimental design and underlying scientific principles Excellent organizational, record keeping, oral and written communication skills Team player, detail oriented and organized
Bachelor Science+8 years or MS+5 yearsCelgene is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Celgene complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Celgene in the U.S.
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