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(Senior) Scientist Translational Dermatology - Netherlands  

ProQR (company)


Posted on : 29 May 2017

Project Description

What we offer!
  • We offer an exciting and innovative working environment within a very committed start-up organization, great colleagues and a lot of fun! 
  • We believe in our strong culture; personal responsibility, flexible workhours and places. Off course we pay a good salary. 
  • You will have a training budget and we will pay your pension and you will get travel allowance. 
  • Do you think you can contribute in achieving our mission AND Do you want to work in challenging environment where your work can really make a difference?

We are looking for a (Senior) Scientist Translational Dermatology
  • As translational scientist you will work with a strong multidisciplinary team to ensure that all scientific aspects of preclinical development are integrated in the development strategy. 
  • You will have to translate preclinical science and bring it into clinical development plans.  
  • You have to communicate and collaborate with the product development teams within our company as well as with outside consultants, academic collaborators and CROs. 
  • You will provide input into preclinical experimental set-up and translate results and assays for clinical development activities including development of bio-marker assays and possible validation of new endpoints. 
  • The translational scientist will work in the dermatology team in close cooperation with other teams in our company.

What are you going to do:
  • Provide scientific rationale for dosing and dosing regimen in the clinic  
  • Work creatively on development of biomarker assays and clinical outcome assessments for ultra-orphan skin diseases 
  • Provide input into preclinical efficacy and functional assays with the aim to ultimately translate suitable candidates into fit-for-purpose clinical assays 
  • Where applicable, help to devise a biospecimen sampling strategy and be in charge of obtaining suitable biospecimens for assay setup and for clinical testing 
  • Develop fit-for-purpose assays for biomarker assays and clinical outcome assessments  
  • Work on trial at home applications 
  • Liaise with external experts (KOLs and/or consultants) and collaborators to accumulate knowledge necessary  
  • Works closely with cross-functional product and expert teams 
  • Attend (scientific) meetings as representative of our company.
  • Contribute to regulatory documents including study reports, Investigator´s Brochures, Clinical Trial Applications and other related documents 

We Ask:
  • PhD with >3 years’ experience in translational science 
  • Hands-on experience with translation of preclinical PK/PD data into a clinical  development strategy 
  • (Ultra)orphan disease drug development is a must 
  • Dermatological experience is a pre 
  • Pediatric development experience is preferred 
  • Creative medicine developer who make things happen 
  • Wanting to work in a dynamic, innovative environment 
  • Excellent communication skills - verbal, presentation, and written (English is a must, Dutch is a plus) 
  • Demonstrated ability to work in a cross-functional environment 
  • Strong data review and interpretation skills 
  • Understanding GC(L)P and ICH Guidelines 
  • Ability to work under pressure 
  • Should enjoy challenging situations and have the flexibility to work in a dynamic and fast-moving environment where there is freedom to act.