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Senior Scientist for pre-clinical analytical method development - Netherlands  

Synthon (company)

Posted on : 20 March 2017

Project Description

Senior Scientist for pre-clinical analytical method developmentAbout SynthonSynthon is an international pharmaceutical company, and a leader in the field of generic human medicines. Founded in 1991, Synthon has been working in biotechnology since 2007 and is developing rapidly into a specialty pharmaceutical company. Our mission is to make health care more affordable, increasing access to important medicines through the provision of high quality generics and new biological and chemical entities - specifically in the therapeutic areas of oncology and autoimmune diseases. Currently our products are approved by regulatory agencies in more than 90 countries and marketed through strategic partnerships and – in dedicated areas – through direct sales.Synthon’s head office is based in Nijmegen, the Netherlands, and the company has affiliates in eight other countries. In 2016 it recorded a turnover of EUR  258 million. The company employs around 1,900 staff of whom over  500 work in Nijmegen.We are interested in result-oriented people with a sharp mind and entrepreneurial spirit, who can contribute to what we do best: delivering affordable medicines to those in need.Job ProfileAs a senior scientist, you are primarily responsible for the development of analytical methods to study the biotransformation of biopharmaceuticals and to develop PK assays. These newly set-up methods will be applied to solve highly complex analytical challenges in support of (pre-)clinical studies, e.g. PK, metabolite ID. To enable that, you have knowledge of state-of-the-art techniques, primarily MS based, in analytical method development and ongoing new developments within that field. You are able to judge which new developments and/or techniques should be implemented, and also to successfully direct that implementation. Most of the work will be carried out in R&D, however, you are also (co-)responsible for the transfer of some of these bio-analytical R&D methods to an (external) GLP/GCP environment. Regulatory requirements should be guiding method development. You are able to work independently and communicate all key issues in a coherent and concise way to key stakeholders. Finally, you will be responsible for coaching co-workers and report writing, but you should especially aspire working at the bench.Your profileYour letter of motivation and CV should show that you have:· A bio-analytical life sciences education (at least a master’s degree, preferably a doctorate)· Preferably experience in a comparable position and/or work environment· Hands-on experience with (pre-)clinical analytical development of chromatographic methods, mostly in combination with state-of-the-art mass spectrometry· Hands-on experience using MS to identify and/or quantify compounds in complex biological matrices, like plasma · Preferably experience with the analysis of biologicals such as monoclonal antibodies and conjugates (and possibly small molecules), and the mechanisms underlying the biotransformation of these compounds in vivo· Excellent command of the English language· Basic knowledge of regulatory requirements for the development of bio-analytical methods.In interviews you will be able to demonstrate that:You can work independently with regard to your scientific tasks, but you are also able to co-operate on all other aspects in your research activities. You have to be able to go out of your comfort zone on a scientific level. You are able to coach people and transfer your knowledge to others which means you are both a team player and a mentor. Your communication skills are excellent, you are flexible and motivated, you work hard and are willing to take over work from others.Important datesPlease send your application before April 3rd 2017. The first round of interviews will take place on April 7th 2017 and the second round will be on April 18th 2017.Information and applicationContract hours: preferably full time.Salary: depending on experience.Location: Nijmegen.For further information please contact Dr. Ruud Ubink, director DMPK at tel. 024 - 372 77 00.If you are interested in this challenging position, we look forward to your application. Please apply via the apply button / link.


Nijmegen Netherlands

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