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Scientist I, Molecular Pathology Cambridge United States,  

Takeda (company)

Posted on : 19 September 2017

Project Description

Are you looking for a patient-focused company that will inspire you and support your career? If so, be empowered to take charge of your future at Takeda. Join us as a Scientist I, Molecular Pathologyin ourCambridgeoffice.

Here, everyone matters and you will be a vital contributor to our inspiring, bold mission. As aScientist I, Molecular Pathologyworking on the Molecular Pathology you will be empowered to use data to help drive molecules into the clinic, and a typical day will include:


  • Provide scientific expertise for state-of-the-art oncology pathology/biomarker analysis for discovery stage and early clinical stage therapeutics
  • Represent Molecular Pathology as a member of project teams to contribute departmental expertise and data to help drive molecules into the clinic
  • Establish scientific methodology for target and antibody validation, and mechanism of action analysis using slide-based expression.
  • Engage in collaborations with related functions including protein sciences,pharmacology, FLOW-based profiling and bioinformatics


  • Develop immunohistochemistry and fluorescence assays, visualization and analysis methods to assess complex cellular phenotypes including immune cell involvement in pre-clinical and clinical tissue samples
  • Perform and manage experimental execution, data presentation and interpretation for target tissue mapping and mechanism of action/biomarker analyses for specific projects/targets
  • Provide scientific insight and collaborate with project teams to design and execute research strategies supporting target/drug interactions, identification of immune components in model systems, and biomarker identification and validation
  • Communicate and collaborate effectively with pathology colleagues as well as cell biologists, pharmacologists, information technologists and external partners in a cross-functional, collaborative team environment
  • Appropriately document and report data to support regulatory filings


  • PhD with >3 years post doctoral research and > 3 years experience in an industry setting related to mechanism of action, pharmacodynamic, and translational strategies for antibody conjugate based or immuno-oncology therapeutics
  • Extensive knowledge of oncology biology, including immuno-oncology, and preclinical/clinical histology/pathology
  • Demonstrated expertise in histology/biomarker techniques relevant to oncology drug discovery
  • Excellent written and verbal communication and presentation skills
  • Record of cross-functional collaboration, as well as some project management capabilities
  • Experience in automated assay development and analysis of human and animal tissue specimens


Cambridge, Massachusetts

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