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Research Scientist, Transporter & Permeability Analysis - United States  

Incyte (company)


Posted on : 28 May 2017

Project Description

Job Summary
  • This position is responsible for conducting transporter experiments and providing Caco-2 permeability analysis of compounds to support discovery efforts. 
  • Candidate should have expertise in the role of transporters in drug absorption and disposition and must have hands-on experience with transporter assays using various in vitro and in vivo models.  

Summary of the Essential Functions of the Job
  • Conduct various in vitro transporter experiments such as uptake and inhibition assays, transcellular transport assays, vesicle transport assays and ATPase assays using transfected cell lines and membrane vesicles. 
  • Maintain Caco-2 cells and provide permeability data to support discovery efforts. Report data weekly to project teams. 
  • Conduct experiments using radiochemicals and analytical techniques including LC-MS/MS in particular. 
  • Write study reports to support IND submission for transporter and in vitro permeability studies when needed. 

Minimum Requirements
  • BS/MS or equivalent in Life Sciences. 
  • 5+ years related transporter and permeability study experience. 
  • Knowledge and hands-on experience with LC/MS/MS is a plus. 
  • Experience with automation studies is a plus. 
  • Be able to quickly adapt to the study setting and conduct permeability experiment as well as generate data within three weeks of employment.