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Research Scientist, Mass Spectometry/Biophysics - United Kingdom  

Company managed [?] Still accepting applications

Posted on : 21 March 2017

Project Description

Description:
  • Our company aspires to be the Patient Centric global Bio pharmaceutical leader, transforming the lives of people with severe diseases. 
  • Due to the significant growth within our New Medicines group we are now looking for an exceptional and talented Research Scientist to strengthen our capabilities. 
  • The Biophysics/Biochemistry Group is responsible for the screening of large panels of different humanized therapeutic candidates from our novel and propriety antibody discovery technology. 
  • This is achieved using a suite of biophysical/biochemical assays and techniques to select robust therapeutic candidates that are stable during manufacture and storage.  
  • We are seeking a high calibre, laboratory-based candidate, with expertise in mass spectrometry, who can quickly integrate into this highly motivated and focused team. 

  
Responsibilities:   
  • Analyse intact, folded antibody/protein molecules using different mass spectrometry methods across a number of research projects and applications. 
  • Identify and flag susceptible post-translational modifications (both in vitro and in the presence of serum) which could impact on product stability. 
  •  Validate n silico prediction packages for hydrophobic/charge patch mapping to predict aggregation stability. 
  • Set up and drive N terminal sequencing using mass spectrometry. 
  • Work flexibly and share expertise with other users of ‘state of the art’ mass spectrometry equipment (orbitrap, ion mobility, QTOF, MALDI-TOF) embedded in a wider mass spectrometry community within company  Research.   
  • Take on a scientific leadership role of mass spectrometry expertise within the Biophysics group, having a positive impact on project progression. 
  • Contribute to the development of novel technology in the Biophysics team. 
  •  Act as an ambassador for company  by proactively communicating science externally via oral communications at scientific meetings and through publications in peer reviewed scientific journals.  


Profile:   
  • A Post graduate/PhD with experience of ‘hands-on’ mass spectrometry characterisation of antibody/protein molecules using a range of different equipment, preferably within an industrial or highly regarded academic laboratory in a Biophysics/ Biochemistry environment. 
  • Proven track record of publications related to mass spectrometry applications in peer reviewed, high quality science journals. 
  • Highly motivated individual with excellent attention to detail and critical data analysis skills. 
  • Exceptional organisational skills with proven ability to deliver to tight timelines. 
  • Flexibility in learning new techniques including biophysical / biochemical analysis skills, particularly to corroborate mass spectrometry analysis. 
  • Excellent communication and team-working ability.       
    

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