Research Scientist-Drug Delivery and Bio-conjugation
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 39,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We re looking for people who are determined to make life better for people around the world.
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The Biotechnology Discovery Research (BioTDR) organization in Eli Lilly & Company is responsible for discovering and optimizing novel biotherapeutics (peptides, proteins, antibodies) for advancement into the clinic in key areas of unmet medical need including diabetes, immunology, oncology, neuroscience, and others. One of the focus areas of the Formulation & Delivery Team (FDT) in BioTDR is to establish physicochemical characterization tools, analytical capabilities, cell-based assays, formulation platforms, and drug delivery strategies to support innovative approaches that enable oral absorption of peptides. This is a cross-functional effort with both discovery and development groups including protein engineering, therapeutic area biology, ADME, chemistry, and small drug and bioproduct development teams to ensure that candidate molecules have the characteristics that ensure successful translation from discovery to the clinic. We are currently looking for a talented, highly-motivated, and technically competent particle engineering and development scientist to become part of our team.
You will focus on development of novel particle formulations with different composition size, surface charge, and release profiles for targeted delivery of therapeutic peptides. If you possess some combination of the skills and experience outlined below, please apply.
Significant hands-on experience in different formulation approaches (e.g. emulsification, precipitation, self-assembly, microfluidics) to develop particles using lipids, natural and synthetic polymers, and other functional materials.
Experience in particle engineering at different scales (bench to pilot) for a wide range of APIs with special interest in formulation of biologics and co-formulation of multiple agents.
Experience in analysis of particle physical/chemical properties, API loading and release, and establishing robust correlation between formulation process and product performance.
As a member of a cross-functional project team, the candidate is expected to collaborate with partners from peptide chemistry, biology, ADME, and development team to define drug delivery strategies and provide stage-appropriate formulations for preclinical studies.
Independently contribute with minimal supervision from the bench (design and execution of studies, critical analysis of data, presentation of results) to inform decisions in a cross-functional team.
Keep abreast of new technologies/capabilities relevant to this role and strive to implement them to push research projects forward.
Author data summaries, technical reports, standard operating procedures, publications, and presentations.
PhD in Pharmaceutics, Chemistry, Chemical/Biomedical Engineering, Material Sciences, or other related fields with relevant expertise
Relevant postdoctoral experience in academia, national/government labs, or pharmaceutical/biotech industry for >1 year
Strong understanding of the interplay between formulation composition and process parameters on formulation performance in vivo and strategies to tune towards a target performance.
A solid research record demonstrated by patents, publications, or presentations in the area of targeted drug delivery, formulation of peptides, and oral bioavailability.
Strong understanding of peptide chemistry, structure, conformation, physicochemical properties, and how this information influence formulation approaches for oral delivery is highly desirable
Interest and ability to work in a dynamic, fast-paced environment, and be capable of handling multiple tasks while meeting timelines
Ability to lead projects and work productively in an interdisciplinary team environment
Excellent oral and written communication skills; Experience with data management software
Flexibility to adjust priorities over time to meet organizational and scientific goals
Some experience with supervision of direct reports
Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
Lilly credits its exceptional employees for its successes, and knows the key to ongoing achievement lies in attracting and retaining the best people. A company rich in heritage, Lilly employs individuals, conducts research and markets products worldwide. By providing for the unmet needs of our customers through a continuous stream of innovation, we will outgrow all competitors. Lilly earns consistent and wide recognition for creating an exceptional work environment:
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