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At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 39,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.
The Department of Drug Disposition (ADME/DMPK) is a multidisciplinary group, utilizing in vitro, in vivo, and in silico approaches to study the pharmacokinetics, absorption, and disposition of new chemical entities. It is a great time to join our group as we continue to build for the future. We are seeking a Research Scientist, who will have primary responsibility for the drug disposition and metabolism-related aspects of the development and registration of small molecules. Scientific leadership and collaboration with technical experts and external labs will be a crucial component of the job.The successful candidate will have hands-on experience and deep understanding of drug clearance mechanisms, in vitro ADME tools, and pharmacokinetics. You will also have the opportunity to
Provide ADME/DMPK expertise and scientific leadership for the nonclinical and clinical development and registration of drug candidates.
Lead collaborative research projects to increase mechanistic understanding of clearance and distribution processes and improve translatability of preclinical models.
Design, conduct, and oversee nonclinical and in vitro ADME studies, utilizing internal labs, outside collaborators, and contract research organizations.
Collaborate on multidisciplinary teams to design and implement Clinical Pharmacology plans.
Collaborate with Toxicologists and Pathologists in the safety assessment of drug candidates.
Write study reports, scientific publications, and global regulatory documents.
Interact with and influence global regulatory agencies.
Contribute to due diligence reviews of external opportunities
Ph.D. in biochemistry, pharmacology, pharmaceutics, pharmacokinetics, or related discipline.
Some additional preferred skills include:
Strong written and oral communication skills, with demonstrated record of publication.
Deep expertise in one of the following areas:
Drug transport and distribution
Drug metabolism and biotransformation pathways
Pharmacokinetics and mechanistic pharmacokinetic modeling
Knowledge of regulatory requirements and industry standards for drug development
Post-doctoral experience studying pharmacokinetics, absorption, metabolism, and distribution of small molecule drugs.
Oncology drug development experience.
Direct experience interacting with global regulatory agencies and contributing to global regulatory submissions.
Experience with designing and conducting clinical pharmacology studies in human subjects.
Training in current PBPK software tools: SimCYP, GastroPlus, etc.
Limited travel required for conferences, external reviews and regulatory meetings.
Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.