BrightOwl Loader Loading

Research Investigator Wilmington United States,  

Incyte (company)


Posted on : 01 May 2017

Project Description

Incyte Corporation is seeking a motivated and experienced protein purification scientist to provide technical expertise in manufacturing process development and optimization primarily through CMOs for new therapeutic biological products including monoclonal antibodies, fusion proteins, and antibody-drug conjugates in early to late stage clinical development as well as commercial launch. 

Job Responsibilities:

  • Oversee purification process development, technology transfer, scale-up, and manufacturing of therapeutic proteins at CMOs
  • Provide technical support to CMOs/partners in optimization of purification process performance at various manufacturing scales
  • Participate in purification process characterization and validation through protocol design and review
  • Provide technical support to continuous improvement in manufacturing process efficiency, product quality, and reduction of cost of goods
  • Support manufacturing campaigns as a Person-in-Plant
  • Participate in routine cross-functional team meetings with partners and CMOs
  • Participate in critical review of manufacturing batch records
  • Participate in writing and review of the CMC sections of IND and BLA documents
  • Perform laboratory purification development work to support manufacturing as needed
  • Other responsibilities as assigned

Qualifications/Requirements: 

  • PhD in biochemistry, bioengineering, biology, chemistry or related fields with a minimum of 5 years of relevant industry experience or a MS degree with a minimum of 8 years of relevant industry experience  
  • Fundamental knowledge in protein chemistry, bioprocessing, and cGMP
  • Fundamental knowledge and hands-on experiences in various types of column/membrane chromatography and filtration technology for cell culture harvest and clarification, protein purification and analysis
  • Experiences in protein purification process development, characterization, and validation for manufacturing biologics drug substances
  • Experiences in purification process scale-up and technical transfer to manufacturing
  • Experiences in using AKTA line of purification instruments from lab scale to pilot scale
  • Experiences in using analytical instruments for protein analysis such as HPLC, capillary electrophoresis, ELISA, light scattering, etc.
  • Good verbal and written communication skills
  • Cooperative, independent, capable of critical thinking and multi-tasking
  • Experiences in Design Of Experiment approach and high-throughput protein purification platform, in interactions with regulatory, QA, QC, and CMO, and in writing CMC section of IND and BLA documents will be a plus

Locations

Wilmington DE

Find a Job Find Candidates

Similar Jobs

More jobs from Incyte

Other jobs in United States

Other jobs in Wilmington

Other jobs from Incyte in Wilmington

Other similar job in Wilmington

Other Jobs

Most Recent Searches

Most Famous Searches

You might also like