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R and D Scientist (28256) - Belgium   we are urgently looking for a R and D Scientist

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Functional titles : Scientist
Project Types : Permanent position ,
FTE : 100 %
Min.Experience : 3 year
Start Date : ASAP
End Date : N/A
Posted on : 04 September 2017

Project is currently here

Step 1
Application
Step 2
BrightOwl Screening
Step 3
BrightOwl Interview
Step 4
Company Screening
Step 5
Company Interview
Step 6
Budgets & Contracts
Step 7
Position filled

Project Description

Description. 

As a Scientist, your overall mission is to design, validate and implement automated high output workflows in our company's R&D biopharmaceutical platform. You will focus on scientific innovations to strengthen our knowledge of the biopharmaceutical properties of the drug substance and drug product, ensuring optimal in vivo performance. 

Your Function 
• Implementation of (semi-)automated high-output in vitro workflows in our company's R&D biopharmaceutical platform to understand and predict the gastro-intestinal absorption potential of new compounds across stages of development. 
• Design, coordinate, execute and report experimental work related to Biopharmaceutics and Physiology Based Pharmacokinetic (PBPK) modeling in support of drug product development. 
• Continuously improve existing workflows based on in silico needs and in vivo performance. 
• Participate in the evaluation of new analytical techniques in the area of biorelevant testing and keep up to date with scientific innovations. 
• Build and maintain strong relationship with key stakeholders including Discovery Sciences, Clinical Pharmacology, Drug Product Development and Analytical Development. 
• Work in a multidisciplinary team of researchers, internally as well as externally

Others

Project FTE 100%
Work from home:   Not Allowed
No. of Positions:   1

Personality

Approachability Adaptability Analytical thinking Attention to detail Communicative Collaboration Curiosity Dependability Efficiency Flexibility Independence Interest in knowledge Responsibility Result Oriented

Knowledge

Biochemistry Cell biology Lab scale batches Labtechnician Automation In Vitro In Vivo Clinical pharmacology drug product development analytical development preformulation biopharmaceutics and physiology based pharmacokinetic

Skills and Expertise

Gastrointestinal diseases drug development in vivo in vitro automation

Degree

Master Ph.D.

Languages

Dutch
Professional Proficiency
Good to have
English
Professional Proficiency
Is a big plus

Desired Skills & Experience

Your Profile • Master or Doctorate (Ph.D.) in Biopharmaceutics, Pharmaceutical Sciences, Biology, Engineering or related science with relevant experience in biopharmaceutics. • Hands on experience with preformulation/biopharmacy related in vitro techniques (e.g. solubility, dissolution, precipitation, solid state characterization, permeability…). • Knowledge of and strong interest in API physico-chemistry, solid state, drug absorption principles, formulation optimization, pharmacokinetics and mechanistic design. • Like to work in the lab and able to perform experiments in state-of-the-art laboratories including using automated platforms • Highly motivated, with excellent organizational, interpersonal, communication, and collaborative skills. • Fluent English (both spoken and written) with excellent scientific writing skills. • Team player, dynamic, stress resistant, innovative and flexible. Assets • Strong interest in working with down scaled and automated high-throughput experimentation and characterization platforms • Understanding of the concepts behind PBPK modelling (Gastroplus/Simcyp) and in vitro biopharmaceutics (e.g. solubility, biorelevant dissolution, particle characterization, solid state characteristics…).