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At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 39,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.
Eli Lilly & Company’s Biotechnology Discovery Research organization is responsible for discovering and optimizing novel biotherapeutic medicines (proteins, peptides, antibodies) for advancement into clinical research in key areas of unmet medical need including diabetes, oncology, immunology, neuroscience, and others. An essential component for commercial success is ensuring that drug candidates have biopharmaceutical properties that enable successful manufacturing, formulation, and drug delivery. The Biotechnology Discovery Research organization has recently created a new Formulation and Delivery Research Team focused on expanding capabilities in the areas of formulation, drug delivery, and early device feasibility assessment. This team will have the opportunity to work cross-functionally between Discovery and Development groups including protein/peptide engineering, biology, ADME, toxicology, and bioproduct Development teams. This expansion has led to the need for qualified scientists motivated to become a part of this exciting new team. There is a unique learning opportunity for motivated new scientists to expand their skill set within this role.
Some key responsibilities might include:
Working closely with protein engineering scientists, peptide chemists, ADME scientists, and biologists to characterize and understand how biophysical and formulation properties of novel biotherapeutic peptides, proteins, and antibodies relate to the overall developability profile of clinical candidate molecules.
Understanding developability profile consists of evaluating a molecule’s physical or chemical stability using a variety of analytical techniques. These include analytical chromatography (HPLC/CE; RP, SEC, CEX, HIC, cIEF, CE-SDS), structural analysis (FTIR, CD, fluorescence, in silico), light scattering (DLS, SLS, zeta potential) and particle counting (HIAC and MFI).
Develop, optimize, and run these analytical and screening methods.
B.S. and/or M.S degree in biochemistry, chemistry, pharmaceutical sciences or related field
Qualified candidates must be legally authorized to be employed in the United States. Lilly does not anticipate providing sponsorship for employment visa status (e.g., H-1B or TN status) for this employment position.
Experience in protein chemistry, biophysical chemistry, formulation research, and/or protein structural analysis.
Current students who are expected to graduate within the next few months are welcome to apply.
Knowledge of and/or experience in protein structure, stability and degradation pathways, protein modeling, protein-protein interactions, and protein formulation optimization is highly desired.
Demonstrated success in working independently and as part of a larger group.
Communication and interpersonal skills necessary to work in a collaborative, cross-functional environment is required.
Hands-on experience with protein biophysical and biochemical characterization techniques is desirable.
Demonstrated ability to learn and apply technical/scientific knowledge to meet changing project needs.
Flexibility to adjust priorities over time to meet organizational and scientific goals.
Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.