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Protein/Formulation Biochemist - United States  

Lilly (company)


Posted on : 10 April 2017

Project Description

32632
Protein/Formulation Biochemist
Indianapolis
Indiana
United States
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 39,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We re looking for people who are determined to make life better for people around the world.
Eli Lilly & Company s Biotechnology Discovery Research organization is responsible for discovering and optimizing novel biotherapeutic medicines (proteins, peptides, antibodies) for advancement into clinical research in key areas of unmet medical need including diabetes, oncology, immunology, neuroscience, and others. An essential component for commercial success is ensuring that drug candidates have biopharmaceutical properties that enable successful manufacturing, formulation, and drug delivery.
The Biotechnology Discovery Research organization has recently created a new Formulation and Delivery Research Team focused on expanding capabilities in the areas of formulation, drug delivery, and early device feasibility assessment. This team will have the opportunity to work cross-functionally between Discovery and Development groups to include protein/peptide engineering, biology, ADME, toxicology, and bioproduct Development teams.
The selected individual for this position will spend roughly half of their time investigating and enhancing the developability characteristics of novel therapeutic molecules through engineering and/or formulation efforts. The other half will be devoted to gaining a better understanding of the subcutaneous compartment and factors affecting bioavailability of parenterally-administered biomolecules. Novel formulation approaches to enhance bioavailability, either through masking a molecule s unfavorable surface property or directly altering the in vivo environment, will be undertaken to facilitate capillary/lymphatic uptake.

Some of the key r
esponsibilities include:
  • Working closely with protein engineering scientists, peptide chemists, biologists, and ADME scientists to characterize and understand how the biophysical and formulation composition of novel biotherapeutics relates to the overall developability profile of clinical candidate molecules.
  • Lead formulation efforts and/or assist in driving SAR to improve on these properties.
  • Work collaboratively across multiple disciplines, as well as provide strong scientific input.
  • Develop and optimize analytical screening methods aimed at identifying molecules possessing properties that enable long-term technical success from pre-clinical through clinical development. Techniques include analytical chromatography (HPLC or CE; RP, SEC, CEX, HIC, cIEF, CE-SDS), structural analysis (FTIR, CD, fluorescence, in silico), light scattering (DLS, SLS, zeta potential) and particle counting (HIAC, MFI).
  • Gaining a more comprehensive understanding of in vivo factors affecting capillary and lymphatic uptake of parenterally-administered biotherapeutics. Novel formulation approaches to enhance bioavailability, either through masking the molecule s opposing surface properties or directly altering the subcutaneous compartment, creating an environment amenable to enhanced capillary/lymphatic uptake will be undertaken.
32632BR
  • B.S degree in biochemistry, biology, pharmaceutical sciences, or equivalent training with a minimum of 6 years post degree experience in a relevant field of research, preferably working with proteins or
  • M.S degree in biochemistry, biology, pharmaceutical sciences, or equivalent training with a minimum of 3 years post degree experience in a relevant field of research, preferably working with proteins
  • Qualified candidates must be legally authorized to be employed in the United States. Lilly does not anticipate providing sponsorship for employment visa status (e.g., H-1B or TN status) for this employment position
  • Hands-on experience in several of the following areas: protein structure, stability and degradation pathways, protein modeling, protein-protein interactions, protein formulation, skin/vascular physiology, cellular receptors, or enzymology is required.
  • Demonstrated ability to learn and apply technical/scientific knowledge to meet changing project needs.
  • Demonstrated success in working independently and as part of a larger group.
  • Communication and interpersonal skills necessary to work in a collaborative, cross-functional environment.
Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status. .

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