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Protein Biochemist - United States  

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Posted on : 15 April 2017

Project Description

Protein Biochemist
San Diego
United States
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 39,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.
The immunogenicity research group at Lilly’s Biotechnology Center in San Diego seeks a highly motivated and skilled scientist with knowledge and research experience in molecular immunology and protein biochemistry. Activities include immunogenicity and pharmacokinetic methods development, validation, and sample analysis. The ideal candidate is a team player, with a passion for scientific research and drug screening, and possessing a broad knowledge of protein chemistry, protein-protein interaction, protein-peptide interaction, immunoanalytical assays, biochemical and biophysical assays, to drive preclinical assessment of biotherapeutic immunogenicity. Some key responsibilities might include:
  • Perform and validate biochemical analysis including, but not limited to, ligand binding assays, protein analysis, 1-D and 2-D PAGE analysis, samples preparation for mass spectrometry.
  • Conduct studies and compile validation protocol, method validation report and SOPs, and ensures that documentation is an exhaustive and correct record of the performed experiments.
  • Carry out sample analysis, validation and data review following GLPs.
  • Perform instrument monitor duties, and routine equipment maintenance as needed.
  • Work with supervisor to discuss laboratory activities and ensure scheduled work is executed as planned.
  • Organize and present data to support decisions in collaboration with immunogenicity scientists and team manager.
Other Key Objectives/Deliverables:
  • Design, screen and analyze data for protein in cell-based assays.
  • Investigate cellular signal transduction, develop cellular activity assays, cytokine/receptor signaling (western, qPCR, intracellular staining and FACS analysis, ELISA, ELISPOT, confocal/image related techniques).
  • Isolation, purification and culture of freshly isolated different populations of leukocyte from human, mouse and rat for ex vivo assays. Preparing cellular materials for genomic and proteomic assessment.
  • Independently design and execute experiments, analyze, interpret and present experimental data.
  • Bachelor's Degree with 2 years of experience or Master's Degree in Immunology, Pharmacology, Biochemistry or similar area.
  • Qualified candidates must be legally authorized to be employed in the United States. Lilly does not anticipate providing sponsorship for employment visa status (e.g., H-1B or TN status) for this employment position.
  • Master’s Degree in biochemical sciences (Biochemistry, Immunology, Pharmacology, or similar disciplines) with research experience
  • Hands-on experience in development, optimization, validation and execution of immunoassays, data collection, data analysis and presentation.
  • Industry experience.
  • Analytical and problem solving capabilities.
  • Ability to work both independently and in a team setting.
  • Able to prioritize work and meet deadlines.
  • Expertise in molecular immunology of human immune system, particularly in antigen presentation and T cell response.
  • Knowledge of pharmacology with experience in ligand/receptor interaction.
  • Experience in the use of common automation equipment such as liquid handlers, and reagent dispensers.
  • Excellent written and verbal communication, work planning, data analysis and record keeping skills (with strong attention to detail).
  • Proficiency with Microsoft Office applications (Excel, Word, PowerPoint) required.
  • Method writing experience on liquid handling platforms and/or laboratory automation scheduling software.
  • Track record of scientific success demonstrated by contribution to high quality publications
Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.