BrightOwl Loader Loading

Principal / Sr. Principal Investigator, Antibody Analytics - United States  

Incyte (company)

Posted on : 01 May 2017

Project Description

Antibody Analytics

Incyte Corporation is a Wilmington, Delaware-based biopharmaceutical company focused on the discovery, development and commercialization of proprietary therapeutics, primarily for oncology. Our first commercial product, Jakafi®, is approved in the U.S. for patients with intermediate or high-risk myelofibrosis and for patients with polycythemia vera who have had an inadequate response to or are intolerant of hydroxyurea. We have a diverse and growing portfolio of product candidates, including both small and large molecules.

Over the last two years Incyte has established a partnership alliance with Agenus for the discovery and development of therapeutic antibodies in the area of Immuno-oncology. This has resulted in the initiation of two clinical development programs and a number of discovery research programs. Recently, the commitment to therapeutic antibodies was reinforced by signing a broad collaboration with Merus B.V. for the discovery and development of bispecific therapeutic antibodies in the area of Oncology.

Incyte is seeking a candidate that has extensive industry experience in analytic / biophysical characterization of antibodies. He/she will be part of a team of scientists focused on the discovery and development of monoclonal and bispecific antibodies for therapeutic applications.

Job Responsibilities

  • Act as an intellectual leader to support ongoing drug discovery programs
  • Become a technology lead in Ab discovery programs, especially on bispecific antibody projects
  • Implement and develop methods for biophysical characterization of therapeutic candidates
  • Work with multiple CROs and Applied Technology Group members to accomplish experimental goals
  • Support activities geared to new target evaluation and validation activities
  • Equip a new lab and establish laboratory activities to conduct biophysical analysis of therapeutic leads

Minimum Requirements

  • Ph.D. in biochemistry, molecular biology, cell biology or related field plus a minimum of 4-6 years of experience in biophysical characterization of protein and antibody (IgG) variants
  • Expertise in the application of various protein biophysical characterization techniques such as DSC, CD, AUC, SEC, light scattering, fluorescence spectroscopy for antibody characterization
  • Experience in antibody engineering and structure-function is highly desirable
  • Prior experience on engineering and analytic characterization / development of bispecific antibody preferred
  • Demonstrated expertise as a technology lead in antibody discovery projects
  • Experience on protein expression / purification preferred
  • Experience on protein structural modeling and design (Rosetta, MOE, Discovery Studio) preferred
  • Has participated in the setting and organization of new analytical groups / laboratories
  • Prior experience working in a matrix environment preferred
  • Demonstrated ability to work in a highly collaborative multicultural team environment
  • Good communication and interpersonal skills, self-driven, creative and entrepreneurial