BrightOwl Loader Loading

Principal / Sr. Principal Investigator, Antibody Analytics Wilmington United States,  


Posted on : 01 May 2017

Project Description

Antibody Analytics Incyte Corporation is a Wilmington, Delaware-based biopharmaceutical company focused on the discovery, development and commercialization of proprietary therapeutics, primarily for oncology. Our first commercial product, Jakafi®, is approved in the U.S. for patients with intermediate or high-risk myelofibrosis and for patients with polycythemia vera who have had an inadequate response to or are intolerant of hydroxyurea. We have a diverse and growing portfolio of product candidates, including both small and large molecules. Over the last two years Incyte has established a partnership alliance with Agenus for the discovery and development of therapeutic antibodies in the area of Immuno-oncology. This has resulted in the initiation of two clinical development programs and a number of discovery research programs. Recently, the commitment to therapeutic antibodies was reinforced by signing a broad collaboration with Merus B.V. for the discovery and development of bispecific therapeutic antibodies in the area of Oncology. Incyte is seeking a candidate that has extensive industry experience in analytic / biophysical characterization of antibodies. He/she will be part of a team of scientists focused on the discovery and development of monoclonal and bispecific antibodies for therapeutic applications. Job Responsibilities Act as an intellectual leader to support ongoing drug discovery programs Become a technology lead in Ab discovery programs, especially on bispecific antibody projects Implement and develop methods for biophysical characterization of therapeutic candidates Work with multiple CROs and Applied Technology Group members to accomplish experimental goals Support activities geared to new target evaluation and validation activities Equip a new lab and establish laboratory activities to conduct biophysical analysis of therapeutic leads Minimum Requirements Ph.D. in biochemistry, molecular biology, cell biology or related field plus a minimum of 4-6 years of experience in biophysical characterization of protein and antibody (IgG) variants Expertise in the application of various protein biophysical characterization techniques such as DSC, CD, AUC, SEC, light scattering, fluorescence spectroscopy for antibody characterization Experience in antibody engineering and structure-function is highly desirable Prior experience on engineering and analytic characterization / development of bispecific antibody preferred Demonstrated expertise as a technology lead in antibody discovery projects Experience on protein expression / purification preferred Experience on protein structural modeling and design (Rosetta, MOE, Discovery Studio) preferred Has participated in the setting and organization of new analytical groups / laboratories Prior experience working in a matrix environment preferred Demonstrated ability to work in a highly collaborative multicultural team environment Good communication and interpersonal skills, self-driven, creative and entrepreneurial

Locations

Wilmington DE

Find a Job Find Candidates

Most Recent Searches

Most Famous Searches

You might also like