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Principal Scientist - Neuroscience - United States  

Company managed [?] Still accepting applications

Posted on : 01 May 2017

Project Description

Few careers offer the opportunity to make a difference in people’s lives. At Amgen, the world’s largest biotechnology company, the Neuroscience Team is committed to serving patients by carrying out innovative science and exploiting new advances in biology and human genetics.

We are seeking a Research Principal Scientist to join a vibrant and growing group currently focusing on Neurodegenerative diseases within the Neuroscience Therapeutic Area, a key component of the Discovery Research unit at Amgen’s site in Cambridge, MA (AMA). The Principal Scientist works with in-depth knowledge of the cellular, molecular and genetic mechanisms underlying neurodegeneration and will participate in ongoing efforts directed toward developing new and effective therapeutics for Alzheimer’s (AD)/Parkinson’s disease (PD).

Responsibilities:
Direct team of Scientists and Associates tasked with identifying, validating and developing approaches for prosecuting new AD and/or PD drug targets.
Lead cross-functional teams that develop innovative strategies for developing new and effective AD and/or PD therapeutics.
Continuously evaluate a variety of in-licensing opportunities and establish external collaborations.
Critically analyze and interpret data, define realistic timelines for studies and meet delivery deadlines.
Work closely with and communicate results to multi-disciplinary and cross-functional teams.
Present strategies and results to Neuroscience and Discovery Research Senior staff.
Execute high impact studies within an extremely fast-paced and collaborative environment.

Basic Qualifications:
Doctorate degree and 3 years of scientific experience
OR
Master’s degree and 6 years of scientific experience
OR
Bachelor’s degree and 8 years of scientific experience

Preferred Qualifications:
Deep expertise in cell biology and genetics underlying AD and/or PD disease and extensive knowledge of the AD and/or PD drug discovery/development space.
Previous experience investigating one or more of the following areas: protein mis-folding and aggregation, protein spreading and seeding, cellular proteostasis mechanisms, vesicular trafficking, neuroinflammation, synaptic dysfunction, from an AD and/or PD drug discovery perspective, with an emphasis on breakthrough innovation and leveraging human genetic validation.
Established scientific reputation in the field of neurodegenerative diseases as evidenced by publication track record.
Experience working in a cross-functional, matrixed, and global Research and Translational organization
Demonstrated ability to recruit, lead and motivate a team of scientists, and to be actively engaged in their career development.
Outstanding leadership, interpersonal and communication skills.

Amgen is committed to unlocking the potential of biology for patients suffering from serious illnesses by discovering, developing, manufacturing and delivering innovative human therapeutics. This approach begins by using tools like advanced human genetics to unravel the complexities of disease and understand the fundamentals of human biology.

Amgen focuses on areas of high unmet medical need and leverages its expertise to strive for solutions that improve health outcomes and dramatically improve people’s lives. A biotechnology pioneer since 1980, Amgen has grown to be one of the world’s leading independent biotechnology companies, has reached millions of patients around the world and is developing a pipeline of medicines with breakaway potential.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.