Principal Scientist, Immuno-oncology, Molecular Medicine - United States
Celgene is a global biopharmaceutical company leading the way in medical innovation to help patients live longer, better lives. Our purpose as a company is to discover and develop therapies that will change the course of human health. We value our passion for patients, quest for innovation, spirit of independence and love of challenge. With a presence in more than 70 countries - and growing we look for talented people to grow our business, advance our science and contribute to our unique culture.
The Molecular Medicine group is a team of scientists, physicians and computational biologists studying the molecular underpinning of disease directly in human tissue samples. We do this via genetic, epigenetic and gene expression profiling, in combination with single cell analysis (e.g. flow cytometry, CyTOF, single cell RNAseq) and spatially-resolved microenvironment profiling (e.g. multiplex IHC). These tumor / immune / stroma data streams are then integrated with a system biology approach to better understand the complex spatio-temporal dynamics of disease biology. To accomplish this, the team not only works with domain experts across the company, but also leverages academic collaborators to access novel tools / capabilities.
The candidate will be an integral part of the Molecular Medicine team to build out these capabilities along with the vice president of translational development, the head of the immuno-oncology research group, the head of computational biology and the executive vice president of business development.
The candidate will function as Molecular Medicine immuno-biology lead and work collaboratively with systems / computational biology team members for key Celgene assets in hematology and oncology (and autoimmune disorders):
- Generate biological hypotheses (e.g., patient selection, drug combinations, new targets) in various oncology (and non-oncology) disease areas arising from interpretation of Molecular Medicine data
- Implement the Molecular Medicine platform by facilitating research collaborations, contracting, experimental design, experimental execution and data analysis
- Collaborate with Molecular Medicine computational and system biology team members to provide scientific input to their in silico disease modeling efforts
She/he will serve generally as a domain expert in immunology and immuno-oncology for the Molecular Medicine team as well as to others in translational development
She/he will collaborate with colleagues in clinical development on translational sample profiling plans to allow discoveries made in the Molecular Medicine group to be confirmed in larger trial settings
As part of the team, the candidate will be responsible for establishing key alliances with academic centers, co-operative groups, and vendors to enable access to relevant tissue types and relevant emerging experimental and computational tools.
Results of the scientific projects of the Molecular Medicine group will provide support to Business Development for potential in-licensing opportunities that may include potential therapeutics, emerging technologies, processes or capabilities that will enhance the Molecular Medicine efforts and the Research and Early Development group more broadly
The candidate will be expected to contribute to publications, study reports, invention disclosures, and investigator brochures, as needed, to a publishable standard.
PhD in a relevant field (Immunology preferred, Hematology or Oncology accepted), with at least 8 years of relevant post graduate experience (biotechnology or pharmaceutical industry strongly preferred).
Expert knowledge of oncology disease areas of interest (e.g., multiple myeloma, lymphoma, solid tumors) or autoimmunity (inflammatory bowel disease, lupus, psoriasis, fibrotic diseases)
Experience with molecular medicine technologies such as next generation sequencing (DNA, RNA, epigenetics), multi-parameter immune profiling (flow cytometry, CyTOF), and IHC, and experience interpreting data from such analyses
Track record in leading innovative efforts to deploy novel technologies and assays via internal or external collaborations
Ability to function at the interface of the Discovery, Development and Commercial teams
Superior leadership, management and organizational skills, and a reputation as an open, available and transparent communicator
Proven ability to collaborate and problem-solve productively as a member of an inter-disciplinary team.
Celgene is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status.
Celgene complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must have authorization to work for Celgene in the U.S.