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Principal Research Scientist-ADME (Absorption, Distribution, Metabolism and Excretion)
Elanco is a global research-based company that develops and delivers product and services to enhance animal health and production. We value innovation, both in scientific research and daily operations, and strive to cultivate a collaborative work environment for more than 7,000 employees worldwide. Founded in 1954, Elanco is a division of Lilly. Our worldwide headquarters and research facilities are in Greenfield, Indiana
This role contributes to the global discovery of new farm and companion Animal Health products by providing ADME (Absorption, Distribution, Metabolism and Excretion) strategy and resourcing for research programs involving small and bio-molecules. This position will ensure that appropriate study designs, protocol development, study execution, and data analysis occurs, and these results are summarized in study reports in compliance with good research practices (GRP). This position will be responsible for determining pharmacokinetic (PK) parameters from in vivo efficacy and exposure studies. This role will also be responsible for interpreting results from high throughput in vitro ADME assays including metabolic stability in microsomes, plasma protein binding and passive permeability run by Contract Research Organizations (CRO). The individual in this role is expected to implement and utilize computational ADMET tools in collaboration with chemistry to inform rational drug design approaches for project needs and issues. The individual in this role is expected to perform key leadership responsibilities which provide innovative solutions, a positive and motivating work environment, and ultimately delivering the Elanco pipeline. This role will also provide leadership and management oversight to research personnel in ADME, toxicology and formulation areas by coaching for success and improvement, encouraging employee growth, developing leaders at all levels, and creating a motivating environment.
Functions, Duties and Tasks
Proactively search for solutions, challenge current default practices, and present effective alternatives for research projects
Work effectively and flexibly within and across all Elanco R&D teams and collaborate with key research partners in chemistry, pharmacology, formulations, and toxicology
Represents research on core teams focused on the discovery and selection of compounds for clinical development.
Work with the medicinal chemistry team to enable ADME hypothesis driven SAR to address physical chemical property challenges
Identify innovative formulation or alternative dosing techniques to address compounds with poor absorption or extensive first pass metabolism.
Providing technical ADME advice and guidance to other teams and business areas within Elanco.
Manage project timeline and budget deliverables to facilitate delivery of the Elanco pipeline.
Outsourcing of pharmacokinetic, metabolite identification and in vitro screening studies through Contract Research Organizations (CROs).
Developing strategies to address issues within projects to optimize drug candidates for entry into farm and/or companion animal development.
Generating, integrating, interpreting and communicating results from in silico predictions, in vitro screening assays and in vivo preclinical studies to research project teams of chemists, biologists and pharmacologists.
Working cross functionally with External Innovation to evaluate potential new opportunities
PhD degree with 7 years experience or Master degree with 15 years experience in ADME (Absorption, Distribution, Metabolism and Excretion) and pharmacokinetics.
Expertise in profiling and interpretation of physicochemical properties of pharmaceutical compounds and the relationship with ADME properties
Experience in supporting research projects and delivering molecules amenable to development
Design and execution of pre-clinical ADME studies in animal health
Expertise in pharmacokinetic principles and drug metabolism impacting in vivo performance
Experience identifying the physicochemical properties of the drug substance necessary to provide acceptable drug product performance.
Ability to multi-task and prioritize workload
Previous experience with WinNonlin or comparable pharmacokinetic calculation software
Domestic travel required (<10%), and some international travel required (<10%).
Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.