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Postdoctoral Researcher Investigating the Role of Phase Transitions and Stress Granule Dynamics in Neurodegeneration - Belgium  

VIB (company)


Posted on : 02 June 2017

Project Description

  • The Laboratory of Neurobiology is part of the research group Experimental Neurology (Neuroscience Department).
  •  The group has a close collaboration with the Neurology Department of the University Hospitals with about 50 researchers in different domains.
  •  In addition, the laboratory is one of the research groups of the Center for Brain & Disease Research focusing on Neuroscience. 
  • There are 13 research groups within the CBD with a total employment of 230 researchers.   
  • The Laboratory focuses on clinical and fundamental research into the prevention, heredity, the pathogenesis and treatment of neurodegenerative disorders such as Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD)

  • The research project will focus on the role of low complexity domains in disease-causing proteins, with a special focus on the dipeptide repeat proteins (DPRs) encoded from the hexanucleotide repeats.
  • Effects of these DPRs on the nucleocytoplasmic transport and stress granule formation will be investigated. 
  • Biophysical techniques will be used to study the structural characteristics and dynamics of these structures. 
  • Moreover, this research will involve in vitro techniques including work with iPSCs, as well as in vivo research using small animal models 
  •  ​We are looking for a highly motivated postdoctoral researcher with interest in neurodegeneration and experience in.
  • Motivated candidates with a strong commitment to basic research are invited to apply. 

The candidate:
  • should hold a PhD degree in biology, biochemistry or biomedical sciences
  • should have experience in research on neurodegenerative disorders
  • should be able to work in a team with a high degree of autonomy
  • should be able to guide and supervise PhD students
  • should fluently speak and write English.

We offer
  • We offer a fulltime 3 year contract for a postdoctoral position in an enthusiastic and motivated team and a dynamic scientific work environment. 
  • The Center for Brain & Disease (CBD) is an international research group focusing on neuroscience. 
  • The CBD provides different opportunities to present and share data on weekly seminars, lectures and international conferences. 
  • Different state-of-the-art core facilities are available for all CBD researchers.