Postdoctoral Fellow, Neurodegeneration and Repair - United States
|External Posting Title||Postdoctoral Fellow, Neurodegeneration and Repair|
|Job Description||The Neurodegeneration and Repair Department at Biogen is seeking a highly motivated, creative and independent Postdoctoral Research Fellow to join Dr. Warren Hirst’ lab which is responsible for bringing new targets and therapeutic strategies from discovery to development for Parkinson’s disease and other movement disorders. The project will focus on the role of glial cells in the pathophysiology of Parkinson’s disease. Genes known to play a causative role in the development of Parkinson’s disease are expressed in astrocytes and microglia, including DJ-1, iPLA2, ATP13A2, LRRK2, GCase, PINK1 and Parkin. Emerging data suggest that these genes play important roles in glial function through their convergence on four main cellular functions; lysosomal function, lipid handling, mitochondrial health and inflammatory responses. Perturbation of these functions, by mutations in PD-genes, results in glial dysfunction, which is hypothesized to be detrimental to surrounding neurons resulting in -synuclein pathology, mitochondrial dysfunction, oxidative stress etc.|
The aims of the postdoc project are to address the following key questions:
• Are glia key players in the development of α-synuclein inclusions in neurons?
• Can healthy glia become overloaded by demand for degradation of high concentrations of extracellular α-synuclein?
• Do pathogenic PD mutations in glial cells result in impaired α-synuclein uptake and / or degradation through the dysfunction in lysosomal function, lipid handling, mitochondrial health and inflammatory responses?
The successful candidate will be responsible for applying a wide range of cellular, biochemical and molecular biology techniques to address these key questions. These will include the development and implementation of protein interaction assays, enzymatic assays, cell-based assays, including primary and iPSC-derived glial cells, and will also include in vivo studies in transgenic and other Parkinson’s disease mouse and rat models.
|Location||Cambridge, MA, US|
|Job Category||Postdoctoral Fellow, Research|
• The successful candidate must possess significant understanding of basic neurobiology of neurodegenerative diseases and mechanisms of neurodegeneration and a strong desire to learn and perform neurology research in an industry setting. Prior experience in glial cell biology is highly desired.
• Strong communication & interpersonal skills and the ability to work effectively in a highly collaborative research environment will be required.
• The successful candidate should have a proven track record of independent research, demonstrated by impactful scientific publications.
|Education||Qualified candidates will have a Ph.D. degree in the areas of Neurobiology, Cell Biology or similar relevant field.|
|About Biogen||Corporate Overview|
Through cutting-edge science and medicine, Biogen discovers, develops and delivers worldwide innovative therapies for people living with serious neurological and neurodegenerative diseases. Biogen is a pioneer in biotechnology and today the Company has the leading portfolio of medicines to treat multiple sclerosis (MS), has introduced the first and only approved treatment for spinal muscular atrophy, and is at the forefront of neurology research for conditions including Alzheimer’s disease, Parkinson’s disease and amyotrophic lateral sclerosis (ALS). Biogen also manufactures and commercializes biosimilars of advanced biologics. Our global organization of nearly 7,000 employees is committed to a single mission: making a meaningful difference in the lives of patients with few or no treatment options.
We aspire to have the greatest impact on patients and science of any biotechnology company in the history of our industry. To us, that means creating novel medicines that benefit individuals and society, and bringing new scientific understanding to diseases for which there are no adequate treatments.
The same intellectual discipline and passion that drives our science is reflected in our corporate citizenship, environmental sustainability, and commitment to diversity and inclusion. As a company, we are focused on improving science education and limiting the impact of our company on the environment. In 2015, we became a carbon neutral company and ranked first place on Newsweek’s 2015 Green Rankings, and we are an industry leader on the Dow Jones Sustainability World Index. Biogen was named to Science’s list of Top Employers of 2015 and in 2017 received a perfect score of 100 for the fourth consecutive year on the Human Rights Campaign (HRC) Corporate Equality Index, which also named Biogen as one of its Best Places to Work.
All qualified applicants will receive consideration for employment without regard to sex, gender identity or expression, sexual orientation, marital status, race, color, national origin, ancestry, ethnicity, religion, age, veteran status, disability, genetic information or any other basis protected by federal, state or local law. Biogen is an E-Verify Employer in the United States.
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