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Postdoctoral Fellow, Neurodegeneration and Repair Cambridge United States,  

Posted on : 02 June 2017

Project Description

External Posting TitlePostdoctoral Fellow, Neurodegeneration and Repair Job DescriptionThe Neurodegeneration and Repair Department at Biogen is seeking a highly motivated, creative and independent Postdoctoral Research Fellow to join Dr. Warren Hirst  lab which is responsible for bringing new targets and therapeutic strategies from discovery to development for Parkinson s disease and other movement disorders. The project will focus on the role of glial cells in the pathophysiology of Parkinson s disease. Genes known to play a causative role in the development of Parkinson s disease are expressed in astrocytes and microglia, including DJ-1, iPLA2, ATP13A2, LRRK2, GCase, PINK1 and Parkin. Emerging data suggest that these genes play important roles in glial function through their convergence on four main cellular functions; lysosomal function, lipid handling, mitochondrial health and inflammatory responses. Perturbation of these functions, by mutations in PD-genes, results in glial dysfunction, which is hypothesized to be detrimental to surrounding neurons resulting in


Cambridge, MA, US

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