Postdoctoral Fellow – Oncology and Inflammation Research - United States
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Dr. J Russell Lipford in the Oncology and Inflammation Research department at Amgen, Inc. is seeking a Postdoctoral Fellow in the area of molecular cellular biology and protein biochemistry.
This postdoctoral project will focus on dissecting the mechanism of Nrf1, an essential mammalian transcription factor that is responsible for proteasome gene transcription in times of proteasome stress. Nrf1 is a type II ER transmembrane protein that is rapidly retrotranslocated into the cytosol by the ER-associated degradation pathway and degraded. If the proteasome is inhibited, Nrf1 is cleaved by the aspartyl protease Ddi2 into a stable and active form that induces new proteasome synthesis. By determining the cellular requirements for Nrf1 processing and recapitulating these key steps in vitro, we hope to develop a mechanistic understanding of the process and potentially develop Ddi2 inhibitors, which might enhance proteasome inhibitor efficacy in tumors.
The assignment length is expected to be 3 years.
PhD at the time of appointment
Molecular cellular biology and protein biochemistry expertise
Membrane protein biochemistry experience
Cellular protein homeostasis experience (translation, modification, degradation)
Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.