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Postdoctoral Fellow  Computational/Systems Biology Cambridge United States,  

Amgen (company)


Posted on : 18 September 2017

Project Description

The Amgen Postdoctoral program is committed to providing future scientists with an enriching environment to inspire innovation that will contribute to the development of human therapeutics.

Dr. Ramsey Saleem in the Attribute Sciences department at Amgen, Inc. is seeking a highly motivated Postdoctoral Fellow in the area of Computational Modeling.
Amgen is seeking a computational biologist to assist in efforts to generate models of the cellular subsystems that are involved in production of biologics in CHO cells. Amgen s interest in this approach results from an applied, medically relevant problem, with significant financial consequences. We seek to understand our system at a level whereby we can systematically predict conditions which result in cells producing high levels of therapeutic proteins with the desired physical attributes. To this end we seek individuals to assist us in.
Generate models of the cellular subsystems that are involved in production of biologics in CHO cells. These include but are not limited to:Golgi mediated N-linked glycosylation
Transcription  chromatin remodeling, RNA processing and export
Translation  ribosome assembly, ribosome progression
Metabolic Flux Balance

Optimize model parameters and refine to generate models with predictive value as done with the Golgi mediated N-linked glycosylation
Link the models together so that the outputs from upstream subsystems provide inputs for downstream subsystems.
Use in-house data to constrain the models and provide Amgen specific solution spaces for the models.

The assignment length is expected to be 2-3 years.


Basic Qualifications
PhD at the time of appointment


Preferred Qualifications
Demonstrated skill in the development of mathematical models of biological processes is critical to the success of the candidate.

Experience in programming is essential

Expertise with statistics is highly desirable.

Candidates with a significant understanding of the biological underpinnings of protein production are highly desirable.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

Only candidates who apply via www.careers.amgen.com will be considered. Please search the database via career category  College Job, requisition R-43797.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

Locations

US, Massachusetts, Cambridge

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