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Postdoc & methods for large-scale dynamic imaging of single cells - Sweden  

Sci Life Lab (company)


Posted on : 20 April 2017

Project Description

The position is located in Johan Elf’s research group where we make theoretical models of central processes in living cells and develop the methods needed to test these experimentally. The goal is to answer fundamental questions about the physical constraints for life at the molecular level, but also for example to show how variations in gene expression can contribute to the development of antibiotic resistance. We are looking for a postdoctoral fellow who wants to work in a curiosity-driven interdisciplinary research team with world-leading research projects. We offer a stimulating research environment at the interface between biophysics, optics and microbiology. This recruitment is part of a KAW funded project that aims to map the physical principles for how proteins search for specific sequences in the genome or transcriptome. The project is an interdisciplinary collaboration of researchers in biology, engineering and physics and you will work closely with several of these groups. The researchers involved are Maria Tenje and Helene Andersson-Svahn that work with microfluidic systems for cell analysis, Mats Nilsson that develops methods for molecular diagnostics in situ, Lynn Kamerlin who investigates of protein-DNA interactions using molecular dynamics simulations and Johan Elf, Magnus Johansson and Sebastian Deindl that investigate molecular interactions and kinetics using high resolution microscopy and single molecule FRET and structure based approaches. Your specific project will make it possible to connect dynamic properties at the molecular level to the underlying genotype of thousands of cells simultaneously. In addition to filling an important gap in fundamental biological research, the method has potential applications for example drug discovery and optimization in biomolecule production.   Mission You will lead the development of new methods to investigate the phenotypic variation in genetic strain libraries and link these to the underlying genotype. The technology is a based on combining microfluidics, advanced optical microscopy and methods for in situ genotyping that are already developed and used in the lab.   Your skills Requirements: You have a PhD in a relevant area, a passion for science and an ambition to do research of high international quality. You have experience in methods development in microbiology, microscopy or microfluidics. Personal qualities such as the ability to lead and manage projects and at the same time be able to interact with other researchers is very important since a significant part of the research will be conducted in collaboration with colleagues from other disciplines. Excellent communication skills in written and spoken English are prerequisites. Meriting: An engineering background and experience working with microfluidic systems, advanced microscopy, biophysics and experimental physics.   Application deadline: April 30st, 2017   More information and instructions for application  

Locations

Stockholm Sweden

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