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Post-Doctoral Fellow Position for CellViewer Barcelona Spain,  


Posted on : 04 July 2017

Project Description

The InstituteThe Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG shares principles of an interdisciplinary, motivated and creative scientific team that is supported by high-end and innovative technologies and a flexible and efficient administration.CRG has been conferred with a badge of ‘HR Excellence in Research’ by the European Commission, in recognition to its progress in implementing the European Charter for Researchers and the Code of Conduct for Recruitment of Researchers, that among others consists of transparent, merit-based recruitment procedures and attractive work-life balance working conditions.For further information: www.crg.eu The roleA unique opportunity is available for a candidate interested in working in a multidisciplinary environment applying advanced optical tools in biomedical research at the Center for Genomic Regulation (CRG)). The successful candidate will be expected to contribute to research in CellViewer FET open project, which is an H2020 European collaborative project. CellViewer (http://www.cellviewer.eu/) focuses on elucidating nuclear architecture and how it regulates nuclear function. The successful candidate will use novel optical tools such as single particle tracking and super-resolution microscopy to resolve the dynamics and sub-cellular localization of nuclear architectural proteins and transcriptional machinery in cells undergoing differentiation. The long-term goal would be to elucidate how molecular complexes coordinate their spatio-temporal organization to activate and repress genes during cell fate transitions. This project overall will give new insights into how cells determine their fate and therefore allow us to have better control over cell fate determination.   Advisor:Maria Pia Cosma, PhDReprogramming and RegenerationCenter for Genomic Regulation (CRG)Barcelona, Spainpia.cosma@crg.eu Co-mentor:Melike Lakadamyali, PhDPerelman School of Medicine, Department of PhysiologyUniversity of Pennsylvania,Philadelphia, USAmelikel@mail.med.upenn.edu About the team/ labPia Cosma’s group is focused on the study of the mechanisms that control somatic cell reprogramming and tissue regeneration, with a focus on dissecting out the function of the Wnt signaling pathway in these processes (http://piacosmalab.com/). Using super-resolution fluorescence microscopy (stochastic optical reconstruction microscopy; STORM) (Rust et al., Nature Methods, 2006) in collaboration with the group of Melike Lakadamyali (Institute of Photonic Sciences, Barcelona) we have dissected out the nanoscale organization of nucleosome assembly, with high molecular specificity and spatial resolution in a variety of somatic and stem/ reprogrammed cells. We have delineated a novel model of chromatin fiber assembly, and the relationship among the decoded structure and na

Locations

Barcelona, Spain

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