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Post.doc in Epigenomics and Genome Replication in the Groth Group København Denmark,  

Posted on : 13 April 2017

Project Description

We seek a highly motivated and independent computational biologist to develop innovative genomic tools to dissect principles of epigenetic cell memory in mammals. Our research/The groupOur research goal is to understand how chromatin is replicated and epigenetic information propagated in dividing cells, and how this impinges on epigenetic changes in disease. We are focusing on mechanisms involved in replication-coupled chromatin dynamics, propagation of DNA methylation and histone-based information. To this end we are applying innovative proteomic and genomic approa­ches in combination with cutting-edge cell biology, advanced imaging and biochemistry. Our key recent publications include: Saredi et al., Nature 534:714, 2016Alabert et al., Genes Dev 29:585, 2015Huang et al., Nat Struct Mol Biol 2015Alabert et al., Nat Cell Biol 16:29, 2014 The research projectThe successful candidate will join a multi-disciplinary team working on how epigenetic information is transmitted in self-renewing cells. In particular, the lab is currently developing a panel of genomic tools to interrogate the impact of DNA replication on epigenome composition and transcription. The candidate will develop bioinformatic pipelines for these tools and optimally also be engaged in the wet-lab application of those tool to fundamental questions in epigenetics including how DNA replication influence transcription factor occupancy and 3D genome organization. Start: 1 September 2017 or after agreementDuration: 2 years with possibility of extension Qualifications and skillsWe expect you to be a highly motivated and ambitious scientist with the following qualifications and skills: A PhD in bioinformatics, computational biology or life sciences Documented experience with NGS data workflow and analysis (e.g. ChIP-seq, ATAC-seq, HI-C, OK-seq, RNA-seq) Experience including a combination of scripting, programming, and statistical analysis Background in epigenomics / genomics Previous experience in cell and molecular biology is an advantage Ability to grasp complex problems and deliver creative, practical solutions Proven ability to envision, plan and execute a research project  Excellent English skills written and spoken The ideal candidate will be a team player and have excellent communication skills. For further information regarding the position, please contact Professor Anja Groth ( Place of employmentThe employment is at BRIC, University of Copenhagen. BRIC is located in the Biocenter, close to the centre of Copenhagen. We offer creative and stimulating working conditions in a dynamic and international research environment. Our research facilities include modern laboratories and a number of core facilities shared between the 23 research groups at BRIC and the neighboring Finsen Laboratory. We have weekly journal clubs, data clubs, seminars with invited speakers and a young researchers club ASAP and our own Postdoc Career Programme and PhD programme, MoMeD. BRIC actively participates in the European alliance, EU-life consisting of 13 excellent life science research institutions Please read more about the Groth research group and BRIC on Terms of salary and employmentSalary, pension and terms of employment will be in accordance with the agreement between the Ministry of Finance and The Academics Central organization. Currently, the monthly salary starts at 32.351 DKK/ca. 4.250 Euro plus pension. Depending on qualifications, a higher salary may be negotiated. Non-Danish and Danish applicants may be eligible for tax reductions, if they hold a PhD degree and have not lived in Denmark the last 10 years. The position is covered by the “Memorandum on Job Structure for Academic Staff at the Universities” of June 28, 2013. ApplicationYour application must be submitted electronically by clicking ‘Apply now’ below or via BRIC’s website on The application must include the following documents/attachments – all in PDF format:   Motivated letter of application (max. one page). CV incl. education, work/research experience, language skills and other skills relevant for the position. A certified/signed copy of a) PhD certificate and b) Master of Science certificate. If the PhD is not completed, a written statement from the supervisor will do. List of publications. Letters of recommendationFurthermore, the applicant should provide two letters of recommendation. To be taken into consideration, the letter must be signed by the supporting person on paper with institutional letter head and in PDF-format. The letters should be received before deadline on with subject “name candidate-Groth-postdoc-2017”; preferably by the supporting person. Please make sure that an easy match between the recommendation letter and the individual applicant is possible. Application deadline: 15 May 2017. We reserve the right not to consider material received after the deadline, and not to consider applications or letters of recommendation that do not live up to the above-mentioned requirements. The further processShortlist: After expiry of the application deadline, the superior with power to appoint selects a number of applicants for assessment on the advice of the Appointments Committee. All applicants are immediately notified whether their application has been passed for assessment. Applicants who were not passed for assessment should not expect further with regard to their application unless the shortlist is revised. Assessment: The selected applications will be assessed according to the Ministry Order on the Appointment of Academic Staff at Universities 2012 and the University of Copenhagen’s guidelines 2013. The Assessment Committee makes a non-prioritized assessment of the academic qualifications and experience with respect to the above mentioned area of research, techniques, skills and other requirements listed in the advertisement. You can read about the recruitment process at BRIC and University of Copenhagen wish to reflect the diversity of society and welcome applications from all qualified candidates regardless of personal background.


1165 København Denmark

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