It is the purpose to perform scientific research and to prepare a PhD on DNA and self-replicating mRNA vaccination against Streptococcus agalactiae in Nile Tilapia. Nile tilapia (Oreochromis niloticus) is one of the most cultivated fish in the world ( > 3.5 million tons), after Carp (Cyprinus carpio). Currently huge economic losses in the tilapia industry occur due to disease caused by Streptococcus spp., especially under intensive culture. Streptococcus agalactiae, long recognized as a mammalian pathogen, is an emerging concern with regard to fish and responsible for mortalities of both cultured and wild ﬁsh species worldwide. We would like to design a DNA vaccine and a self-replicating mRNA vaccine to protect Tilapia against Streptococcus agalactiae disease. During the PhD, new vaccine constructs and vaccine carriers as well as novel administration methods will be used to improve the immunogenicity of these innovative genetic vaccines.
The research will be conducted in the Laboratory for Immunology and Animal Cell Biotechnology of Ghent University, Faculty of Bioscience Engineering, Department of Animal production, Coupure links, 653, 9000 Ghent, Belgium in close collaboration with the Laboratory for Gene Therapy of Ghent University, Faculty of Veterinary Medicine, Salisburylaan, 133, 9820, Merelbeke
Supervision: Prof. Daisy Vanrompay, Prof Niek Sanders and Prof. P. Bossier `
Period: for 1 year with a possibility to prolong till 4 years.
Start of the project: Possible from August 1st 2017
Profile of the candidate
Knowledge of immunology, molecular biotechnology, cell cultures is an added value. Vacant for students who graduated in July 2017 or earlier.
How to apply
Please send your application (motivation lettre + CV) before the 15th of July 2017 to: Prof. Dr. D. Vanrompay Vakgroep Moleculaire Biotechnologie Faculteit Bio-ingenieurswetenschappen, UGent Coupure links, 653 9000 Gent Tel: (0)9 2645972; Fax: +32(0)9 2646219 E-mail: Daisy.Vanrompay@ugent.be Send your application also to Prof Niek Sanders: Niek.Sanders@ugent.be