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PhD student Ghent Belgium,  

Posted on : 13 May 2017

Project Description

Long acting injectable formulations (LAIs) offer many opportunities across different therapeutic areas, e.g. to ensure treatment adherence. Over the years, a lot of expertise has been built in the area of aqueous suspensions of micro- or nanoparticles, which are injected intramuscularly to obtain the long acting effect. However, the chosen technology is complex and can only be used in a chemical space where the drug substance has a very low aqueous solubility. Hence, several initiatives have been started to allow the development of future LAIs using a more integrated approach, combining novel ideas in the chemical space, with physiologically relevant in vitro dissolution data and relevant animal release data, which can be used to generate mathematical models to make the overall process more predictive. The candidate we are looking for will have the opportunity to work on the development of these future LAI formulations, more specifically in the area of Biopharmaceutics. Profile of the candidate For the Faculty of Pharmaceutical Sciences, we are looking for: an enthusiastic, full-time PhD student within the Department of Bioanalysis. Candidates preferably have an interest in pharmacokinetics and/or mathematics and are willing to learn how to perform pharmacokinetic modeling analyses. The candidate will work in a dynamic team environment at the interface of the long-acting injectable (LAI) formulation work and the in vivo behavior of these LAIs, characterizing the release determining factors and aspects of these novel formulations. The candidate will set up novel biorelevant in vitro dissolution methods and animal experiments with candidate LAIs that have been fully characterized in vitro, to obtain the necessary data for PK modeling analyses. Important skills include: Good academical skills and grades Excellent written, oral and interpersonal communication skills Profound knowledge of the English language Willing to work with advanced PK analysis software to perform compartmental modeling analyses Be able to start in July 2017 on a full-time basis. Candidates will be offered a 4-year contract. How to apply All applications must contain the following documents attached as one file: application letter CV a transcript of the required degree an overview of your relevant scientific publications, if available other relevant information All applications or requests for further information


9000 Ghent Belgium

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