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Posted on : 12 April 2017
DEVELOPMENT OF EX VIVO CARTILAGE TISSUE MODELS AND APPLICATION OF COMPRESSIVE FORCE TO STUDY OSTEOARTHRITIS BIOLOGY AND TREATMENT NORDIC BIOSCIENCE IS LOOKING FOR A HIGHLY MOTIVATED PHD-FELLOW THE PROJECT There are currently no disease modifying treatments for osteoarthritis, presenting a clear and urgent medical need for patients. Osteoarthritis is in the general public often described as a simple wear and tear disease, but the ethiology has proven much more complex. The underlying pathology, involves a series of different demographic and biological risk factors, one of them being mechanical loading. Mechanical loading is essential for the maintenaince of normal articular cartilage, but is also a key factor in osteoarthritis and not just in the notion of simple wear and tear of the joint. Mechanical changes such as gait changes, trauma, obesity and malalignment of the knee have been associated with molecular changes in the joint remodeling processes. In contrast, physical activity in healthy adults without OA symptoms reduces the risk of cartilage thinning, defects, and bone marrow lesions also exemplifying the protective role that joint loading can exert on biochemical and biomechanical physiology. Consequent to osteoarthritis related mechanical and molecular processes, changes occur in the composition and turnover of the extracellular matrix which can be measured as biomarkers from tissue cultures through in vivo, to clinical seetings, providing a unique translational analytical tool. Ex vivo models of different joint tissues related to OA pathology, and in particular cartilage, have shown great promise as a preclinical tool to evaulate pathological processes, validate potential biomarkers, and as useful tools in providing early preclinical proof of concept for upcomming novel therapeutics targeting the joint. With that in mind, the overall objectives of this project are: To develop a mechanically stimulated cartilage tissue model (ex vivo) with both bovine and human tissue. Further to use this model to test potential new treatments for osteoarthritis. Use existing protein fingerprint biomarkers reflecting joint remodeling, to evaluate mechanical and treatment effects on joint tissue remodeling. Develop novel protein-fingerprint biomarkers reflecting joint ECM remodeling in relation to mechanical load. The biomarkers will be evaluated for the association with tissue pathology and clinically relevant endpoints. YOU We seek a highly motivated and enthusiastic PhD student to join our team of dedicated scientists and technicians in the Rheumatology group. You hold a master degree in biology, biochemistry, biotechnology, molecular biomedicine or similar education.
2730 Herlev Denmark
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