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Non Clinical Drug Discovery Lead - Belgium  

UCB (company)


Posted on : 09 December 2016

Project Description

Our promise is to help tackle the serious unmet medical needs affecting patients around the globe. An important part of our philosophy is to take a holistic approach to patients, which aims to find solutions tailored to their circumstances. By taking into account patients’ individual characteristics and lifestyles, such as age, diet, family history and genetic profile, we are also coming closer to providing personalized therapies. We are now looking for our New Medicines department at our research site in Belgium for a: 
Non-Clinical Drug Discovery Lead  (Expertise in Safety Biomarkers or Discovery Toxicology)

Nature and scope
We’re looking for a capable and energetic leader with experience in discovery toxicology and/or safety biomarker development / implementation who will head up a small group of talented scientists. The ideal candidate will have 10 years plus experience in drug discovery/development with key experience in early safety in vitro toxicology and/or safety biomarker development.  Experience in our key therapeutic areas, as well as large and small molecule development is desirable but not essential.  Similarly, experience in managing a small group of scientists is desirable but not essential. 

Major Accountabilities 
  • Provide scientific, strategic & technical leadership for in vitro safety toxicology in order to identify, investigate and derisk mechanisms of toxicity and/or,   
  • Provide scientific, strategic & technical leadership in  safety biomarkers to identify biomarkers of toxicity in preclinical species that will translate to man as well as provide a screening tool to derisk safety liabilities identified in pre-clinical toxicity studies.       
  • Lead and mentor a molecular toxicology laboratory  to include 1 scientist, 1postdoc & 2 students.
  • Develop in vitro mechanistic safety toxicology or biomarker studies for technology transfer and outsourcing to CROs.   
  • Participate as a Principal Investigator with conventional and state of the art techniques. 
  • Attend scientific congresses and publish abstracts and/or papers in reputable scientific journals.  
  • Establish internal and external collaborations in the field of investigative, mechanistic safety toxicology and/or  safety biomarkers.   
  • Strong communication skills and the ability to work within cross-functional teams.   
  • Develop appropriate collaboration with external partners, academic institutions, CROs and consultant toxicologists.  
  • Provide outstanding toxicology assessments of non-clinical safety studies or safety biomarker  studies.  
  • Provide significant contributions to project teams as an investigative safety specialist / project representative to support the development of new innovative medicines.         

  • PhD or equivalent (MD, DVM, in Toxicology and/or Biomarkers). 
  • Minimum 10 years post-doc experience with experience in toxicology, in vitro toxicology and/or biomarkers. 
  • Strong knowledge in the field of toxicology with emphasis on in vitro systems and/or biomarkers supported by a proven publication record.   
  • Experience in NBEs and/or NCEs 
  • Experience and working knowledge in techniques appropriate to the role such as in silico models, in vitro models, in vivo models, qualitative and quantitative biomarker analysis. 
  • Prior experience in management (i.e. students, postdocs, scientists, laboratory support staff) 
  • Excellent planning and strategic skills to successfully drive laboratory-based activities. 
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