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Mechanical and structural alterations after surgical treatment of osteoarthritis - Belgium  

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Posted on : 26 August 2017

Project Description


Osteoarthritis(OA) is the most prevalent chronic joint disease. There is no cure to OA.Surgical treatment is performed in severe cases to reduce pain and to improvemobility. Due to longer life expectancy and the tendency to perform initialsurgery at younger age, classic joint arthroplasty is facing increased revisionsurgery. In an attempt to postpone or obviate joint arthroplasty a renewedfocus is seen on joint preserving corrective surgery. With this project we aim toimprove our understanding on (i) the alterations in joint loading followingsurgery, on (ii) the accompanying alterations in bone microstructure, and on (iii)how the structural alterations are related to alterations in joint loading.


We are seeking to expand our team with a PhDstudent to quantify the alterations in mechanical load in OA-affected knee jointsbefore and after surgical treatment. Specifically, we will measure bonemicrostructure in OA patients using high-resolution ConeBeamCT and will monitorthe alterations occurring within two years following treatment. Experimentaland computational biomechanics will be used to quantify the alterations inmechanical load following treatment. These data are highly needed to improvetreatment of OA.


The candidate shouldhave a recent MSc (or be close to graduating) in Biomedical Engineering,Mechanical Engineering, or other relevant discipline. Knowledge and experiencein bone and cartilage mechanics, finite element analyses, programming andexperimental testing are advantageous. Good skills in spoken and written Englishare mandatory.


We offeran interdisciplinary research project at the Biomechanics Section at KU Leuven,with close interaction and collaboration with clinical departments in Leuvenand Kortrijk as well as with several research groups in Europe. The candidatewill be supported by the Arenberg Doctoral School offering a versatile trainingprogram that addresses both academic expertise and personal skills. Salariesare highly competitive and in accordance with KU Leuven regulations.