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Executive Director, Systems Oncology Analytics Group Job Boston United States,  


Posted on : 22 April 2017

Project Description

Executive Director, Systems Oncology Analytics Group-BIO004804DescriptionMerck is a global health care leader with a diversified portfolioof prescription medicines, vaccines and consumer health products, as well asanimal health products. Today, we are building a new kind ofhealthcare company  one that is ready to help create a healthier future forall of us.Our ability to excel depends on the integrity, knowledge,imagination, skill, diversity and teamwork of people like you. To thisend, we strive to create an environment of mutual respect, encouragement andteamwork. As part of our global team, you ll have the opportunity tocollaborate with talented and dedicated colleagues while developing andexpanding your career.We are currently recruiting for a key individual to leadcomputational biology and data analysis activities for Merck s oncology programs,and to contribute to efforts in other immune-related therapeutic areas. ThisExecutive Director must have scientific excellence in the field ofcomputational biology, leadership and management skills to direct a growing groupof individuals, and excellent communication skills. This individual will have acritical strategic and tactical role in overseeing the scientific direction ofprograms involving immuno-oncology, molecular oncology and cross-therapeuticarea initiatives. The Executive Director will have the opportunity to guide thecollection and analysis of an unprecedented wealth of translational data fromMerck s oncology programs and partnerships, and to lead initiatives withrelevance for other immune-related disciplines such as vaccines, infectiousdiseases and autoimmunity/ inflammation.More broadly, computational biology is a key area of growth for Merck,and the Executive Director will have significant leadership responsibilities inshaping the enterprise-wide direction of these activities.This Boston or South San Francisco-based position will report intothe VP of Genetics and Pharmacogenomics (GpGx). The qualifiedindividual will be a recognized expert in field of computational biology with deepexperience in systems immunology, oncology and/or immuno-oncology. Thisindividual will assume a leadership role in a dynamic cross-functionalenvironment, developing experimental and bioinformatic approaches to understandthe immune context and molecular underpinnings of cancer, and using theinsights to inform novel therapeutic and biomarker strategies. Thecandidate will also develop other projects focused on cross-functional,immune-related efforts. In addition toproviding strategic and operational leadership, the incumbent will lead a teamof multiple direct reports with significant growth potential. Additionally, thecandidate will be a member of the Translational Oncology Leadership Forum,consisting of key functional area leaders including discovery biology, GpGx,computational biology, discovery biomarkers, statistics and IT, and companiondiagnostics. This group coordinates cross-functional activities and sets andexecutes the strategic vision for oncology translational research. Thecandidate will also participate in other cross-functional strategy forums. He/shewill be expected to operate in a highly collaborative and matrixed environment,partnering with peers on site and at other locations in New Jersey,Pennsylvania and globally. This position will also require leadershipto deepen and expand an already extensive network of external partners,including leading academics, nonprofits, and technology/informaticscompanies.Keyresponsibilities:Interface and collaborate internally andexternally with biologists, geneticists, physicians, pathologists, and otherbioinformatics scientists to investigate mechanisms of antitumor immunity,tumor immune evasion and oncogenesis, and define novel immune-relevant ormolecular targets. Use translational datasets to help set strategy for Merck s biomarkerdiscovery and patient stratification approaches in oncology, and guideexperimental and clinical study design as appropriate.Lead a growing group of world-class computational biologists,who will analyze an extensive and rapidly expanding body of genomics andbiomarker data from internal and external clinical and pre-clinical genomicsdata sources. This dataset is expected to be of unprecedented wealth andcomplexity, deriving from Merck s industry-leading immuno-oncology clinicaldevelopment programs as well as an extensive network of externalpartnerships. Provide insights intonovel mechanisms of response and resistance that will support targetidentification and validation, and growth of the Merck oncology portfolio. Identify and develop novel predictive,pharmacodynamic and safety biomarkers, generate hypotheses relating to patientstratification, and inform indication selection and clinical trial design. Leadpartnering efforts with external academicians, nonprofits and technologycompanies to support these efforts. Present results and provide scientificreports and strategic recommendations as needed or requested by project teamsas a component of project reviews, milestones, governance and externalinteractions related to portfolio.Influence and shape company-wide bioinformaticsstrategy. Provide regular input to the larger team and drive strategy aroundthe acquisition and sharing of information regarding specialized biomedicaldatabases, innovative computational methods and advances in genomics.Facilitate bringing in data / knowhow or learning into the broader organization inparticular, by leveraging activities in Oncology to facilitatecross-therapeutic area initiatives.QualificationsEducation Requirement:A minimum of a PhDdegree (with at least 10+ years' experience) in bioinformatics, immunology,computational or statistical sciences or related field with research in one ormore aspects of cancer immuno-biology.Specificresponsibilities include:- Participatingas part of 8-person leadership team (including VP) in developing, anddriving, the strategy to identify and prioritize programs entering theearly pipeline across all therapeutic areas.- Leading a growingteam  including the hiring of new, outstanding scientists in computationalbiology- Participatein the Translational Oncology Leadership Forum, including ~12cross-functional scientists- Workingwith information technology and statistical sciences colleagues, developbest practices and expand capacity for data storage, sharing andstewardship and data visualization.Desired attributes:- Prior experience in relatedareas with expertise in computational methods, tools and databasesutilized in genomic and genetic data analysis. Relevant academic or industryexperience is highly desired.- Specific expertise in systems immunology, oncology and/or immuno-oncology ishighly desired.- Project experience in biomarkerdiscovery, mechanisms of action of drug candidates, correlatinggenomic/genetics data with clinical and biochemical phenotypes.- Proven ability to providetestable hypothesis to project teams based on systematic analysis of datafrom pre-clinical and clinical studies.Expertise in a range of biological databases (e.g. TCGA, ICGC,etc.) and use for translational or basic research. Experience withpublicly and commercially available bioinformatics pathway/networkanalysis tools, genomics and genetics databases.- Experience in applyingcomputational systems biology or integrative analysis approaches tofacilitate interpretation and hypothesis generation from results ofgenetics, genomics and epigenetics studies, preferably in a crossfunctional setting.- Hands-on experience ofanalyzing data generated using one or more of the following:- Microarrays-- Expression / Genotyping,- NextGeneration Sequencing platforms,- Flowcytometry with emphasis on immunophenotyping,- Proteomics.- Single-cell-basedanalytics (genomics and proteomics).- Experience to include pathwaylevel data analysis and interpretation. Familiarity with one or moregenomics platforms from vendors such as Illumina, Complete Genomics,Affymetrix etc. around applications such as WGS, Exome Capture-Seq,RNA-Seq and ChIP-Seq, Microarray based Expression, micro RNA, DNAMethylation and Genotyping.- Outstanding computationalbiology programming skills in scripting or programming languages such asR, Python, Perl, C/C++ etc. and related bioinformatics packages.Contributions to external scientific community through presentations andparticipation in appropriate scientific conferences and through otheravenues such as journal articles, book chapters.- Experience managing a team ofbioinformaticians- Experience in cross-functional,highly matrixed collaborative groups- Excellent communication skillsthat can cross technical areasOur employees are the key to our company s success. We demonstrate our commitment to our employees by offering a competitive and valuable rewards program. Our Company s benefits are designed to support the wide range of goals, needs and lifestyles of our employees, and many of the people that matter the most in their lives. If you need an accommodation for the application process please email us at staffingaadar@merck.com.Search Firm Representatives Please Read Carefully:Merck & Co., Inc. is not accepting unsolicited assistance from search firms for this employment opportunity. Please, no phone calls or emails. All resumes submitted by search firms to any employee at Merck via email, the Internet or in any form and/or method without a valid written search agreement in place for this position will be deemed the sole property of Merck. No fee will be paid in the event the candidate is hired by Merck as a result of the referral or through other means.Visa sponsorship is not available for this position.For more information about personal rights under Equal Employment Opportunity, visit:EEOC PosterEEOC GINA Supplement Merck is an equal opportunity employer, Minority/Female/Disability/Veteran  proudly embracing diversity in all of its manifestations. Job: Biology-DiscoveryJob Title:Executive Director, Systems Oncology Analytics GroupPrimary Location: NA-US-MA-BostonOther Locations: NA-US-CA-San FranciscoEmployee Status: RegularNumber of Openings: 1Company Trade Name:Merck Nearest Major Market: Boston Job Segment: Oncology, Biochemistry, Biotech, Genetics, Pathology, Healthcare, Science

Locations

Boston, MA, US

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