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Computational Modeler/ Programmer Barcelona Spain,  


Posted on : 07 May 2017

Project Description

The Centre for Genomic Regulation (CRG), is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 43 countries, the CRG excellence is based on an interdisciplinary, motivated and creative scientific team that is supported by high-end and innovative technologies and a flexible and efficient administration.CRG has been conferred with a badge of ‘HR Excellence in Research’ by the European Commission, in recognition to its progress in implementing the European Charter for Researchers and the Code of Conduct for Recruitment of Researchers, that among others consists of transparent, merit-based recruitment procedures and attractive work-life balance working conditions.For further information: www.crg.euThe Sharpe GroupThe Sharpe lab focuses on the incredible process of how millions of cells control their decisions and movements during embryo development, to create intricate organised tissues and organs such as hearts or hands. This phenomenon can be seen as a form of distributed information-processing, where the gene regulatory circuits, which are identical in every cell of the organism, allow cells to integrate multiple signals from their neighbours to decide: which movements to make, which cell types to differentiate into and which communication signals to send out in return. We have had recent success in starting to understand this process for limb development, through a systems biology approach which tightly integrates experimental data with computer modelling, demonstrating that:·         finger patterning is achieved by a Turing reaction-diffusion system of interacting molecular signals (Sheth et al. Science 2012, Raspopovic et al. Science 2014).·         this molecular system appears to be conserved from fish to mammals (Onimaru et al. Nature Communications 2016)·         we can reverse-engineer a gene circuit that specifies cell position along the proximo-distal axis (Uzkudun et al. Molecular Systems Biology 2015).The PositionWe are now seeking another computer modeller to join the group, to implement and use software for efficient exploration of how 3D gene expression patterns regulate each other, and control the distribution and orientation of active cellular behaviours. The candidate should have strong experience in computer modelling, and ideally in parallel processing such as CUDA on GPUs. Experience in any of the following will be beneficial: agent-based modelling, gene regulatory circuits, 2D and 3D mesh generation and manipulation, data-visualisation, optimisation and parameter estimation. The Sharpe lab is interdisciplinary, and the candidate will have the opportunity to work closely with experimentalists while developing their research project. RequirementsStudies: ·         PhD in computing, engineering, physics, maths or related topicTechnical skills required:·         Strong programming skills·         Experience in computer modelling (finite element methods, networks, circuit dynamics)Desirable Experience:·         Experience in agent-based modelling – ideally of biological systems·         Experience with high-performance computing with GPUs and CUDA or OpenCL  ·         Systems Biology and gene regulatory networks·         Optimisation and parameter estimation·         Data visualisation in 2D and 3D·         3D mesh generation, analysis, transformation, morphometrics·         The ideal candidate will have enthusiasm and/or experience in developmental biology.Languages: ·         Fluent level of English.  The Offer·         Duration: Till the end of the project with an estimated end date of the 31st of December 2018·         Estimated annual gross salary: A competitive salary will be provided, which will be well matched relative to the cost of living in Barcelona, and adjusted according to experience.·         Starting date: Immediate hiring We offer work in a highly stimulating environment with state-of-the-art infrastructure, providing the successful applicant with unique opportunities to develop a strong technical portfolio.CRG offers and promotes a diverse and inclusive environment and welcomes applicants regardless of age, disability, gender, nationality, race, religion or sexual orientation.Application ProcedureAll applications must include:1.     A presentation letter addressed to Dr. James Sharpe.2.     A full CV including contact details. (3.     Two contacts for further references. All applications must be addressed to Dr. James Sharpe and must be submitted online through the official website of the CRG - http://recruitment.crg.eu/.Deadline: Please submit your application by 14th of May 2017El contrato ser

Locations

Barcelona Spain

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