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Cell Biology Scientist - Italy  

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Posted on : 22 March 2017

Project Description


Description:
  • We are currently seeking a Cell Biologist experienced in human induced pluripotent stem cells (hiPSC) to strengthen our cell-based assay development capabilities for our research and customer projects. 
  • The successful candidate should be familiar with general cell biology laboratory techniques and have direct working experience in handling h-iPSC and related tasks, including: somatic cell isolation, h-iPSC derivation, generation of differentiated cell types, disease modelling, genome editing and in vitro drug screening.
  •  Activity in the development and validation of miniaturised, functional cell-based assays for HTS using h-iPSC derived cells (such as neuronal cells and cardiomyocytes) will be the primary task of the successful candidate.
  • A Ph.D. in Cell Biology/ Molecular Medicine/ Pharmacology is ideal.


Candidates must have a thorough understanding and strong practical experience in the followings:
  • Reprogramming human somatic cell lines into induced pluripotent stem cells (h-iPSCs); 
  • Expanding h-iPSCs in culture and banking h-iPSCs for research use; 
  • Maintenance and scale up cultures for h-iPSCs and their differentiation toward different  lineages, such as neuronal cells and cardiomyocytes; 
  • Development of disease modelling assays through assessment of physiologically relevant  phenotypes; 
  • Setting up, maintaining, and efficiently operating cost effective laboratory operations; 
  • Preparation of cells to meet the demands of multiple projects; 
  • Familiarity with basic pharmacological concepts for receptors, ion channels and  transporters. 


The following skills would be advantageous:
  • Genome editing of h-iPSC lines for mutation introduction and correction, KI, KO, reporter   gene insertion; 
  • Development of cell based assays, for different targets and using different readout systems; 
  • Working knowledge of Microsoft Office programs (Excel, Word, PowerPoint); 
  • Use of GraphPad Prism; 
  • Familiarity with lab automation: plates and liquid-handling devices; 
  • Fluent/good spoken and written English; 
  • Ability to follow instruction closely, but also to work independently as required; 
  • Good team player; 
  • Ability to work to tight deadlines with a sense of urgency. 



Equal opportunity employer
Our company  offers a stimulating work environment and a competitive salary.