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(Associate) Scientist or Senior Technician (Technology development) Leiden Netherlands,  

ProQR (company)

Posted on : 08 June 2017

Project Description

We are looking for a (Associate) Scientist or Senior Technician (Technology development)
  • We are looking for a new team member to work on the cell culture-based validation of new RNA-targeting oligonucleotide technologies. 
  • You will join our innovative technology development team that works on establishing new therapeutic platform technologies for a range of different disease indications. The work is mainly lab-based, so we expect you to have a proven track-record of meticulous and precise day-to-day lab work.
  •  You will work together with other scientists and technicians on state-of-the-art approaches, so being motivated by scientific and technical challenges is essential.
  •  You should be able to independently move from planning to experimentation, have good troubleshooting skills, and report promptly and accurately. 

Primary Tasks:
  • Oligonucleotide screening in cell culture 
  • Analyze oligonucleotide localization in subcellular compartments 
  • Immunohistochemistry in cell and tissue samples 
  • Design, plan and execute (a series of) experiments 
  • Analyze experiments and prepare data reports 
  • Keep up to date with the scientific/technical developments and improve methods accordingly 

We ask:
  • BS/MSc/PhD in biochemistry, genetics or a related field 
  • Min. 4 years of experience of day-to-day lab work in an industrial/academic setting 
  • Expertise in intracellular trafficking, organelles, and cell biology of the nucleus  
  • Essential technical skills (required):      
    • Confocal microscopy, including quantitative (e.g. segmentation) image analysis 
    • Immunohistochemistry 
    • Western blotting, ELISA and other enzymatic assays, protein expression and purification 
    • Molecular cloning, RNA and DNA extraction, quantitative RNA analysis methods 
    • Culturing and transfecting cell lines and primary cells   
  • Desirable technical skills (not required but advantageous):      
    • Experience with NextGen sequencing platforms 
    • Interest in bioinformatics and structural biology; basic knowledge of programming languages (e.g. C, Python) 
    • Experience with RNA-protein interactions 
    • Experience with oligonucleotide therapies   
  • Essential soft skills:      
    • Excellent writing and communication skills (English) 
    • Strong interpersonal skills; a team player; and overall, a nice person! 
    • Flexibility to function well within a team environment, condensed timelines, and fast-changing priorities 
    • Strong project management and organizational skills   

  • We offer an exciting and innovative working environment within a very committed start-up organization, great colleagues, a competitive salary, and a lot of fun. 
  •  Do you want to be part of our devoted team of enthusiastic professionals?
  •  Do you think you can contribute in achieving our mission?
  •  Do you want to work in challenging environment where your work can really make a difference?
  •  If so, we re looking forward to receive your application by filling out our application form 


2333 CK Leiden The Netherlands

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