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Associate Scientist - Oncology In Vivo Pharmacology - Belgium  

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Posted on : 10 April 2017

Project Description


Janssen Pharmaceutica joined the Johnson & Johnson group in 1961. Today, Janssen Pharmaceutica is one of the most innovative pharmaceutical companies in the world and employs more than 4,000 professionals in Belgium. Our research and development centre develops products for a wide range of disease areas, such as mental disorders, neurological problems, infectious diseases, immunological disorders, cancer, and cardiovascular and metabolic conditions.


The Associate Scientist will join the Oncology in vivo group efforts in the pharmacological characterization and development of small molecules and biologics including those that function as immune modulators for the treatment of cancer. Responsibilities include but are not limited to:

Design, execute and interpret complex in vivo studies for the validation and characterization of targets or therapeutic agents in the areas of oncology and tumor immunology

Establish and perform in vivo model development, target inhibition, efficacy, and pharmacokinetic/ pharmacodynamics (PK/ PD) biomarker studies in rodents

May perform bioluminescent imaging studies using molecular reporters or disseminated/ metastatic disease models

May contribute to ex vivo analysis of tumor or immune cells by FACS, IHC, ELISA, RT-PCR, or Luminex

Occasional weekend, evening, and holiday dosing/ animal monitoring required

Manage multiple in vivo experiments simultaneously

Analyze and present data in a clear presentation ready format

Contribute to various projects outside of his/her own, collaborate with stakeholders from all relevant functions, and keep up-to-date in the literature related to his/her field

Act as an expert resource on project teams, and demonstrate clear and professional verbal and written communication


Qualifications
  • Hiring level will be commensurate with education and experience.
  • Bachelor’s degree (BS/ BA) or equivalent (upper school/non-university) in the life sciences (molecular/ cellular biology, biochemistry, pharmacology, tumor immunology) with at least 4-8 years of relevant pharmaceutical or biotech industry/ lab/ academic experience OR a Master’s degree (MS) with at least 3-5 years of relevant experience is required.
  • Cell culture of cancer or immune cells is required.
  • Experience with oncology relevant rodent models - xenografts and syngeneic models are required; primary grafts, orthotopic models, humanized models, or genetically engineered tumor models are preferred.
  • Must have experience with small molecules and/or biologics.
  • Strong skills in tumor implantation techniques and dosing (po, iv, ip, routes), tumor measurement, health monitoring, and data collection and analysis are required.
  • Experience with bioluminescent imaging, FACS, IHC, ELISA, RT-PCR, Westerns, or Luminex® is desirable.
  • Ability to effectively present scientific data and concepts to colleagues and teams is required, and experience presenting at external meetings is desirable.
  • Experience in writing technical drafts for IND (US-FDA) or CTA (EMA) filings is preferred.

Specific Requirements

  • Working fluency in English
  • Accreditation or Certification of Regularization by Federation of European Laboratory Animal Science Associations (FELASA), or similar foreign certification
What’s in it for you…?
“Caring for the world, one person at a time…”
As an employee we consider you as our most valuable asset. We take your career seriously.
As part of a global team in an innovative environment your development is key and our day-to-day responsibility. Through e-university, on the job training, various projects and programs, we ensure your personal growth.
Our benefits make sure we care for you and your family now and in the future.

Primary Location
Belgium-Antwerp-Beerse
Organization
Janssen Pharmaceutica N.V. (7555)
Job Function
R&D
Requisition ID
1700156770W