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Associate Scientist, Molecular Biology - United States  

Company managed [?] Still accepting applications

Posted on : 26 February 2017

Project Description

Description
  • Our company  is a global biopharmaceutical company leading the way in medical innovation to help patients live longer, better lives. 
  • Our purpose as a company is to discover and develop therapies that will change the course of human health. 
  • We value our passion for patients, quest for innovation, spirit of independence and love of challenge. 
  • With a presence in more than 70 countries - and growing we look for talented people to grow our business, advance our science and contribute to our unique culture. The key therapeutic platforms currently under investigation leverage a broad range of biological activities that allow for the development of novel paradigm-changing therapeutics. 
  • Our discovery research teams are organized into four Thematic Centers of Excellence (TCoE), including Protein Homeostasis, Epigenetics, Immuno-oncology and Inflammation & Immunology. 
  • Within each these areas, discovery research, translational research, and early clinical development are integrated into a single team.  


Summary/Scope:   
  • The Protein Homeostasis TCoE is built on our legacy IMiD compounds. 
  • This class of drugs targets “undruggable” proteins including Ikaros and Aiolos for degradation, thereby achieving therapeutic efficacy in a range of human diseases, e.g. multiple myeloma, DLBCL and lupus, etc. 
  • The early drug discovery team in the PH TCoE is now seeking a full-time associate scientist to assist the development of novel small molecular agents targeting other undruggable proteins for degradation to treat a variety of human diseases.   
  • The successful candidate will utilize state-of-art biotechnology tools to define the underlying mechanism of response and resistance to novel cereblon modulating agents, and help devise rational combination to increase therapeutic efficacy and overcome drug resistance. 
  • The understanding of mechanism of action of these agents will help us identify the right disease indications and select sensitive patient population.   
  • The successful candidate will work collaboratively in a multi-disciplinary environment,  and will have the opportunity to work closely with discovery project teams and scientists across the PH TCoE functional areas and to present his or her work at project team meetings and to the senior research leadership.   


Responsibilities will include, but are not limited to, the following:  
  •  Plan and execute scientific experiments related to one or more programs 
  •  Design research protocols in collaboration with the principal investigator 
  •  Assist senior researchers in executing, conducting analysis and reporting results 
  •  Familiarity with literature and internal best practices to identify opportunities to improve productivity and quality of work 
  •  Perform high-throughput screen to uncover novel substrates of cereblon E3 ligase complex 
  •  Perform CRISPR library screen 
  •  Generate stable cancer cell lines via retroviral or lentiviral transduction 
  •  Conduct routine cell culture tasks 
  •  Conduct various cell based assays to characterize drug candidates 
  •  Interprets data, troubleshoots and recommends corrective actions for routine problems 
  •  Maintain an accurate, comprehensible, current laboratory journal 
  •  Train others on new skills and procedures 
  •  Communicate results in written and oral presentations  
  •  Write protocols, procedures and technical reports


QualificationsSkills/Knowledge Required:   
  • Bachelor’s degree in a scientific discipline with at least 6 years research experience or Master’s degree with at least 4 years research experience 
  • Extensive wet-lab experience in biochemistry, molecular and cell biology 
  • Knowledge of cancer biology and cutting-edge next-generation sequencing (NGS) methods  
  • Highly motivated and strong team player with a high degree of independence 
  • Innovative and critical thinking 
  • Excellent time management and organizational skills 
  • Strong communication skills, both written and oral