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Associate Scientist II, ALS Target Validation Research - United States  

Biogen (company)


Posted on : 07 May 2017

Project Description

Job Description
  • The Department of Neurology Research is seeking a highly talented and enthusiastic associate to join an in vitro / in vivo target discovery and validation effort in Amyotrophic Lateral Sclerosis (ALS) aimed at bringing new targets and therapeutic strategies from discovery to development. 
  • The successful candidate will be expected to support efforts to develop and validate new in vitro ALS models for candidate identification and validate findings in primary mouse tissue.
  • The successful candidate must have a MS in the Biological Sciences, and will be charged with developing high content assays that will be used to validate genes and pathways identified in genetic screens that affect neurodegeneration. 
  • The ideal candidate will have previous experience using cell based methods to investigate neurodegeneration. 
  • Experience with biochemical analytical methods such as gel electrophoresis, Western blot, ELISA-type assays, qRT-PCR, as well as immunohistochemistry and immunofluorescence on cells and tissues is important. 
  • The candidate will also need experience using AAV or lenti viral transduction approaches as well as experience with RNAi technologies. 
  • It is strongly desirable that the candidate has experience basic mouse handling experience with basic surgical techniques. 
  • Very strong communication skills are critical for the position as is the ability to work effectively in a highly collaborative research environment. 

  • Must possess significant experience in mammalian cell culture techniques; preferentially also in culturing primary neuronal cells, viral transductions and RNAi delivery. 
  • Possess significant experience in immunohistological techniques, including tissue processing and sectioning, immunostaining, microscopy techniques and image analysis.
  • Possess significant experience in a variety of biochemical analytical methods, including gel electrophoresis, Western blot, ELISA, protein extraction and qRT-PCR.
  • Basic experience in rodent-handling, including excellent surgical skills (stereotaxic injections), experience with handling, dosing of rodents, and collecting tissues (brain) and fluids (CSF, plasma). 
  • Experience developing novel cell-based assays (e.g. microfluidics), functional endpoints and high-content screening (preferred).
  • Strong interpersonal and organizational skills, including patience and steady commitment towards achievement of set goals and capacity to maintain detailed written records of research (required).
  • Keen knowledge of independent experimental design, underlying scientific principles, and the ability to analyze and assess results. 
  • Understanding of basic neurobiology of neurodegenerative diseases and mechanisms of neurodegeneration is preferred. 

 MS in biological sciences and minimal 5 years of relevant experience in academia or industry 

About Us 
  •  Through cutting-edge science and medicine, our company discovers, develops and delivers worldwide innovative therapies for people living with serious neurological and neurodegenerative diseases. 
  • Our company  is a pioneer in biotechnology and today the Company has the leading portfolio of medicines to treat multiple sclerosis (MS), has introduced the first and only approved treatment for spinal muscular atrophy, and is at the forefront of neurology research for conditions including Alzheimer’s disease, Parkinson’s disease and amyotrophic lateral sclerosis (ALS).  
  • Our company  also manufactures and commercializes biosimilars of advanced biologics.   
  • Our global organization of nearly 7,000 employees is committed to a single mission: making a meaningful difference in the lives of patients with few or no treatment options.  
  • Our company  was founded in 1978 and today serves patients in nearly 70 countries.  
Our Science 
  •  We aspire to have the greatest impact on patients and science of any biotechnology company in the history of our industry.  
  • To us, that means creating novel medicines that benefit individuals and society, and bringing new scientific understanding to diseases for which there are no adequate treatments.  
  • For nearly two decades our company has led in the research and development of new therapies to treat MS, including the most prescribed oral treatment in the world. 
  •  Now our research is driving revolutionary new MS treatments with the goal of reversing or even repairing damage caused by the disease. 
  • We are now applying our neurological expertise to solve some of most challenging and complex diseases of the brain, including Alzheimer’s disease, Parkinson’s disease, and ALS. 
  • As we uncover new insights into human biology, our company is employing cutting-edge technologies to discover potential treatments for rare and genetic disorders.  
  • Our company  is revolutionizing biologic manufacturing, developing the industry’s most advanced plants and processes. 
  •  This expertise is used to produce both original innovative therapies and bio similar that expand patient access to lower-cost medicines.  
Our Corporate Citizenship 
  •  The same intellectual discipline and passion that drives our science is reflected in our corporate citizenship, environmental sustainability, and commitment to diversity and inclusion. 
  •  As a company, we are focused on improving science education and limiting the impact of our company on the environment. 

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