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(Associate) Scientist Exploratory Pharmacology - TEMP 1y - Belgium  

Ablynx (company)


Posted on : 12 March 2017

Project Description

  • We’re offering a temporary full time position for an (associate) scientist with a strong background in animal disease models and bioanalytical assay development, to strengthen the Exploratory Pharmacology team.
  • The Exploratory Pharmacology team supports all aspects of early assessment of novel Nanobody® drug candidates in relevant in vivo models or ex vivo test systems during preclinical development in disease areas such as haematology, inflammation, infection, allergy and oncology.
  • The main responsibilities for the Exploratory Pharmacology team are to outline the early in vivo/ex vivo proof-of-concept strategy, selection of appropriate animal models (mechanistic and/or disease-relevant), study design, data analysis and interpretation of results. 
  • In addition, the team is responsible for the development of pharmacokinetic (PK) assays, immunogenicity (ADA) assays and biomarker assays in support of the in vivo studies.

Key responsibilities:
  • You will design and implement preclinical proof-of-concept strategies to allow transition of promising drug candidates from discovery to late non-clinical testing 
  • You will coordinate in vivo/ex vivo studies, manage collaborative relationships with academic and industrial collaborators and internal parties 
  • Scientific responsibility for pharmacokinetic and immunogenicity analysis of Nanobodies in various species. 
  • More specific, you will supervise the development and qualification of assays (e.g. ELISA, MSD based) including study sample analysis. 
  • Ensure transfer of successful projects to late non-clinical teams 
  • You will be an active member of departmental and cross-departmental project teams that guide our different internal or partnered programs 
  • You will interact with project leaders and supervisor on a regular basis to synchronize the planned work versus the time lines 
  • You will contribute to scientific discussions and drive technical project progress 
  • You will write and review study plans and reports (reporting language is English)

  • PhD. in Biomedical Sciences, Biotechnology or related disciplines. 
  • More experienced candidates are also encouraged to apply as entry level will depend on relevant experience. 
  • Strong scientific background 
  • Experience in designing and conducting in vitro, ex vivo and in vivo studies 
  • Experience in analytical method development 

  • Ability to work independently with minimal supervision 
  • Excellent problem-solving skills 
  • Quick learner with ability to adapt to rapidly changing priorities 
  • Strong communication (verbal, written, interpersonal, listening) skills 
  • Team-oriented 
  • Excellent time management and organization skills 
  • Ability to multi-task and meet timelines in a fast-paced environment