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Assoc. Dir / Director, Structural Biology - United States  

Incyte (company)


Posted on : 10 July 2017

Project Description

  • Our company is a fast growing biopharmaceutical company focused on the discovery, development and commercialization of proprietary therapeutics, primarily for oncology. 
  • We are part of the S&P 500 and named one of the Forbes most innovative companies in the U.S. 
  • Our first commercial product, Jakafi?, is approved in the U.S. for patients with intermediate or high-risk myelofibrosis and for patients with polycythemia vera and projected to reach $1 billion in annual sales this year. 
  • We have a diverse and growing portfolio of product candidates, including both small and large molecules.
  • Our company employees enjoy a rewarding fast paced work environment, competitive compensation, an affordable cost of living and close proximity to Philadelphia, Baltimore, D.C. and the New Jersey and Delaware beaches.
  • Our company  is seeking a candidate with industry experience to build and integrate structural biology capabilities using a combination of internal and external resources. 
  • He/she will provide structural biology support for company discovery programs and interact broadly with the Medicinal Chemistry and Discovery Biology teams. 
  • The successful candidate will have extensive experience with protein structure determination using x-ray crystallography and have determined multiple novel structures. He/she will be responsible for rapid and iterative structure determination in support of small molecule structure-activity relationships.

Job Responsibilities
  • Provide structural biology expertise in support of our company discovery program 
  • Institute crystallization, data collection and structure solution capabilities using internal and external resource 
  • Act as a key member for drug discovery project teams and interact directly with medicinal and computational chemist 
  • Participate as member of the new target discovery team and provide expertise in evaluation of chemical tractability 
  • Experience with protein NMR and/or computational biochemistry is a plus  

Minimum Requirements
  • Ph.D. in chemistry, biochemistry or related field, plus a minimum of 8 years of experience in structural biology 
  • Proven experience supporting drug discovery programs with structural biology method 
  • Good communication and interpersonal skills 
  • Proven experience managing direct and indirect reports 
  • Self-driven, creative and entrepreneurial with ability to support multiple programs simultaneously