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Assoc. Dir. / Director, Bispecific Antibody Discovery Wilmington United States,  


Posted on : 13 May 2017

Project Description

Bispecific Antibody Discovery Incyte Corporation is a Wilmington, Delaware-based biopharmaceutical company focused on the discovery, development and commercialization of proprietary therapeutics, primarily for oncology. Our first commercial product, Jakafi®, is approved in the U.S. for patients with intermediate or high-risk myelofibrosis and for patients with polycythemia vera who have had an inadequate response to or are intolerant of hydroxyurea. We have a diverse and growing portfolio of product candidates, including both small and large molecules. Over the last two years Incyte has established a partnership alliance with Agenus for the discovery and development of therapeutic antibodies in the area of Immuno-oncology. This has resulted in the initiation of two clinical development programs and a number of discovery research programs. Recently, the commitment to therapeutic antibodies was reinforced by signing a broad collaboration with Merus B.V. for the discovery and development of bispecific therapeutic antibodies in the area of Oncology. Incyte is seeking a candidate with extensive industry experience in discovering and developing biotherapeutic antibodies. He/she will play a critical role as part of a team of scientists focused on the discovery and development of bispecific antibodies for therapeutic applications with an emphasis on oncology. Job Responsibilities Provide broad intellectual leadership to the antibody discovery team Act as individual contributor focused on supporting the Merus partnership and the development of the Ab group Will have a crucial role in establishing a working relationship with the Merus counterpart Interface with Merus and Incyte colleagues in the design of projects and their strategic execution Represent Applied Technology Group on project discovery teams Work with multiple CROs and Applied Technology Group members to accomplish experimental goals Responsible for protein engineering / optimization activities Participate on new target evaluation and support validation activities geared to target nomination Minimum Requirements Ph.D. in biochemistry, molecular biology, cell biology or related field, plus a minimum of 8 years of experience in antibody discovery and engineering Proven expertise directing antibody discovery projects for therapeutic applications Comprehensive experience in antibody discovery by immunization and/or display technologies Good communication and interpersonal skills Experience with discovery and development of bispecific antibodies preferred Strong background on protein engineering and optimization Experience on protein structural modeling and design (Rosetta, MOE, Discovery Studio) preferred Strong background on biophysical characterization analysis preferred Experience in fragment engineering preferred Proven experience managing direct and indirect reports Self-driven, creative and entrepreneurial

Locations

Wilmington DE

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