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A PhD Fellowship in Chromatin Dynamics and DNA replication in the Groth Group at BRIC København Denmark,  

Posted on : 13 April 2017

Project Description

We seek a highly motivated candidate to investigate the molecular mechanisms governing chromatin replication in mammals. The group and our researchOur research goal is to understand how chromatin is replicated and epigenetic information propagated in dividing cells, and how this impinges on epigenetic changes in disease. We are focusing on mechanisms involved in replication-coupled chromatin dynamics, histone chaperone function, and propagation histone-based information. To this end we are applying innovative proteomic and genomic approa­ches and carryout structure-function studies using cutting-edge cell biology, advanced imaging and biochemistry. Our key recent publications include:Saredi et al., Nature 534:714, 2016Alabert et al., Genes Dev 29:585, 2015Huang et al., Nat Struct Mol Biol 2015Alabert et al., Nat Cell Biol 16:29, 2014 The research projectThe successful candidate will join an ERC-supported team investigating how replication impacts on establishment and maintenance of gene expression programs. During cell division, epigenetic information in chromatin must be transmitted to daughter cells in order to maintain cell identity or commit to a developmental program. However, it remains unknown how epigenetic states are inherited during cell division. The candidate will investigate the provision histones to sites of DNA replication by histone chaperones as part of a multi-disciplinary team including proteomics experts and structural biologist. The project will involve mapping of histone chaperone networks and functional characterization of novel histone chaperones using a combination of explorative proteomics, biochemistry, genome-editing, epigenomics and advanced imaging. Start: Preferably 1 September 2017 or after agreement.Duration: 3 years as a PhD + 6 months as research assistant Qualifications We expect you to be a highly motivated and ambitious scientist with the following qualifications: A MSc in Life Sciences Documented experience in protein biochemistry and/or cell and molecular biology Experience in structure-function analysis, genome-editing, NGS technologies, protein complex purification and imaging is an advantage Background in chromatin biology, DNA replication, structural biology or genome stability Proven ability to plan and execute a research project  Excellent English skills written and spoken The ideal candidate will be a team player and have excellent communication skills. To be considered for the position as PhD fellow, it is a condition, that your Master of Science degree is considered to be equivalent to a Danish Master of Science ( For further information regarding the position, please contact Professor Anja Groth ( Place of employment and Work The employment and place of work is at BRIC, University of Copenhagen. BRIC is located close to the centre of Copenhagen, in the Copenhagen Biocenter. We offer creative and stimulating working conditions in a dynamic and international research environment. Our research facilities include modern laboratories, a number of cutting-edge core facilities shared between the 23 research groups at BRIC and the neighboring Finsen Laboratory and a well-functioning administrative and technical support. We have weekly journal clubs, data clubs, seminars with invited speakers and a young researchers club ASAP and our own PhD programme, MoMeD. BRIC actively participates in the European alliance, EU-life consisting of 13 excellent life science research institutions More about BRIC and Groth Group on Terms of salary and employment The appointment as PhD fellow is for 3 years. It is conditioned upon the candidates' success­ful enrolment in the PhD programme. This requires submission and acceptance of an application for the specific project formulated by the candidate during an initial short-term employment as a research assistant for 6 months. The PhD study must be completed in accordance with The Ministerial Order on the PhD programme (2013) and the University's rules on achieving the degree. Salary, pension and terms of employment are in accordance with the agree­ment between the Ministry of Finance and The Danish Confederation of Professional Associations on Academics in the State. Depending on seniority, the monthly salary begins around 25.759 DKK (ca. 3.435 EUR) plus pension. Application Your application must be submitted electronically by clicking 'Apply now' below or via BRIC's website on The application must include the following documents/attachments – all in PDF format:   Motivated letter of application (max. one page) Curriculum vitae incl. education, experience, language skills and other skills relevant for the position A certified/signed copy of Master of Science certificate. If not completed, a certified/signed copy of a recent transcript of records or a written statement from the institution or supervisor will do Publication list (if possible)   Letters of recommendation Furthermore, the applicant should provide two letters of recommendation. To be taken into consideration, the letter must be signed by the supporting person on paper with institutional letter head and in PDF-format. Send the letters before deadline to with subject "candidate's last name-Groth-PhD-2017"; preferably by the supporting person. Please make sure that an easy match between the recommendation letter and the individual applicant is possible. Application deadline: 18.May 2017 We reserve the right not to consider material received after the deadline, and not to consider applications or letters of recommendation that do not live up to the above-mentioned requirements. The further processShortlist: After expiry of the application deadline, the superior with power to appoint selects a number of applicants for assessment on the advice of the Appointments Committee. All applicants are immediately notified whether their application has been passed for assessment. Applicants who were not passed for assessment should not expect further with regard to their application unless the shortlist is revised. Assessment: The selected applications will be assessed according to the Ministry Order on the Appointment of Academic Staff at Universities 2012 and the University of Copenhagen's guidelines 2013. The Assessment Committee makes a non-prioritized assessment of the academic qualifications and experience with respect to the above mentioned area of research, techniques, skills and other requirements listed in the advertisement. You can read about the recruitment process at BRIC and University of Copenhagen wish to reflect the diversity of society and welcome applications from all qualified candidates regardless of personal background.


1165 København, Denmark

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