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Posted on : 01 July 2017
- The stability of the genome is constantly challenged by DNA damage, which is recognized as a driving force in cancer development.
- DNA repair has to occur within the context of chromatin and chromatin acts both as a barrier and a regulator of DNA repair.
- We have recently shown for the repair of DNA double strand breaks (DSBs) by homologous recombination that chromatin can be in two states, which are either permissive or restrictive for homologous recombination
- In the context of the collaborative research cluster SFB 1064, we aim (I) to characterize these two states (e.g. chromatin-associated factors, histone modifications, etc) in a systems biology approach. Moreover, we aim (II) to use an in vitro reconstituted system to identify the biochemical mechanism of specific chromatin-associated factors that promote or impede repair by homologous recombination.
- Since these factors determine which pathway is used for the repair of the DSB our findings will reveal how cells control DNA repair pathway choice.
- These projects will therefore not only give fundamental insights into a basic cell biological mechanism, but also have a critical impact on future gene editing approaches (e.g. CRISPR/Cas9).
- recent degree (MSc or equivalent) in Biochemistry, Biology or a related discipline of the Life Sciences
- very high interest in basic cell biology
- independent worker
- strong commitment and work ethic
- strong background in lab techniques (project I molecular cell biology; project II biochemistry)
- high interested in interdisciplinary approaches
- open for international cooperation
- an internationally competitive PhD project in a young, ambitious and successful research team
- world-leading facilities and experimental support at the company Institute of Biochemistry
- productive collaborations within the Research Cluster Chromatin Dynamics and with international experts in the field of genome stability
- plentiful opportunities to further develop professional skills within a multi-disciplinary research team
- a 3-4 year structured PhD program with possible additional courses at the company Institute of Biochemistry
- a 65 percent position, pay level TV-L E13
82152 Martinsried Germany
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