To whom it may concern...
Dear Sir (Madame)!
Having a good experience in different areas of synthetic and analytical chemistry; radiochemistry and nanotechnology I should like to devote final stage of my career to the solution of concrete problems of industrial production of human drugs, formulations or related area.
I am looking for a job in the field of bioorganic chemistry, nanotechnology, synthetic or analytical chemistry or related arears.
I have good experience, skills and expertise in following arears:
Peptide synthesis either solid phase or in solution including purification, analysis and scaling up the production. As well, I have a good experience in synthesis of amino acid derivatives even at a big scale.
Solid phase synthesis of DNA/RNA, purification, analysis, synthesis of monomers and solid supports for oligonucleotide solid phase synthesis.
Synthesis of hybrid and chimera compounds such as peptide-oligonucleotide conjugates, DNA/RNA chimeras, their purification, analysis, synthesis of linkers and supports for stepwise synthesis.
Production of nanoparticles, modification of their surfaces with cell penetrating, targeting peptides and oligonucleotides.
Radiolabeling of small and large compounds for in vivo imaging, including development and optimization of labeling methods, purification and characterization of radioactive compounds.
I am familiar with most basic methods of organic and bioorganic synthetic chemistry, methods for purification, analysis and characterization of compounds such as HPLC, flush chromatography, mass spectrometry, NMR, UV and IR spectrometry.
I have experience in lecturing, supervision of PhD. and graduate students, in preparation of practical and theoretical courses in the area of synthetic chemistry.
I am familiar fish most science and presentation related software and have good presentation skills.
During last 8 years, I am acting as an academic editor in PLOS ONE scientific journal and I have good editorial and writing skills.
Working last 10 years in a big multidisciplinary team, I have very good communication skills and understanding how to fulfill requirements of my colleagues from related arears.
I am learning rather fast and can get into any new area related with organic chemistry if it will be necessary for my new job.
I am an opened minded person having creative thinking and good sense of humor, can be either a leader or good team player.
My languages are:
University researcher Helsinki, Finland
Since August 2006
1.08.2006 I have a position in the group of Prof. Arto Urtti, DDTC, faculty of Pharmacy, University of Helsinki. I started the research in the field of structure – activity relations in cell penetrating peptides and development of peptide-based systems for gene delivery and cell targeting, trying to apply my chemical skills in the field of biopharmacy. From 2007, my field of interest also include design, synthesis and property studies of surfactant like peptides. Synthesis, isolation and purification of different compounds of oligonucleotide nature, such as primers, siRNA, antisense oligonucleotides, and preparation of monomers and building blocks for solid phase oligonucleotide synthesis are also a part of my research duties.
From 1.03.2008 I have a position of a university researcher in CDR (Centre for Drug Research, University of Helsinki) leaded by Professor Arto Urtti. In addition to the topics mentioned starting from this time my research field also includes synthesis of nanoparticles and modification of their surface with different peptides displaying cell penetrating and targeting properties in order to adjust targeted delivery of gene and gene related materials. From the year 2008, I also act as an academic editor in PlosONE journal.
In the year 2014, I have a permanent position in the University of Helsinki, faculty of Pharmacy as a head of laboratory. Starting from this time my duties include also development of methods for radiolabelling of different compounds for in vivo SPECT/CT imaging and support of group members with synthesis of different bioorganic and organic compounds required for their research especially related to protein and nucleic acid chemistry. My job also includes preparation of lecture and practical courses for students
Senior researcher Kuopio, Finland
October 2002 --- June 2006
2003-2006 I was working as a senior researcher in the department of Pharmaceutical Chemistry, University of Kuopio, Finland. Research field is synthesis of peptides, modified olygonucleotides, peptide-oligonucleotide conjugates and conjugate libraries, development of novel supports, reagents and methods for solid phase synthesis of oligonucleotides and peptide-oligonucleotide conjugates; isolation, purification and characterization of those novel compounds. During last years, I dedicated a lot of my activity to the development of novel solid supports suitable for either solid phase stepwise synthesis of peptide-oligonucleotide conjugates or serve as polymeric universal supports for DNA / RNA solid phase synthesis. That work ended up with patent and patent applications mentioned in the list of my publications (11, 12, 15, and 16). During last four years I kept giving a lecture and practical course on peptide synthesis for graduate, postgraduate students of Kuopio University, and supervise two PhD students in the area of solid phase synthesis
Analytical thinkingAttention to detailCollaborationCommunicativeCreative thinkingEfficiencyFlexibilityIndependenceIndividualityInterest in knowledgeOptimismKindnessProblem solvingResponsibilitySelf-disciplineTrust
Scientific writingAnalytical ChemistryAnalytical methodsAnalytical techniquesBiochemistryChemistryChemistry, Manufacturing, and Controls (CMC)ChromatographyData AnalysisDNADrug DeliveryDrug DiscoveryElectrophoresisgas chromatographyGrant PreparationGrant Writinggrant writing and designHPLCLaboratoryLaboratory ResearchLaboratory ManagementLaboratory TechniquesLarge MoleculesLC-MSLiquid Chromatography-UV (LC-UV)Liquid chromatography–mass spectrometry (LC-MS)Mass SpectrometryMicrosoft OfficeMicrosoft ExcelMicrosoft PowerpointMicrosoft WordNanotechnologyNMRNucleic Acid ExtractionOrganic ChemistryPeptidesPharmaceutical ResearchProtein PurificationPurificationResearchScientific WritingScientific methodologyTeachingTechnical reportsUnderstand levels of research evidence
Skills and Expertise
Analytical skills Develop protocols Lab scale batches Write papers Write protocolsAdjust methodsAdjust processes Analyze data/information to determine potential relationships.CommunicationCommunicate effectively on different company levelsConduct literature searchesConduct university research CoordinationDesign protocolDesign protocolsdrafting grant applicationsEvaluate impurity identificationEvaluate impurity synthesisEvaluate physico-chemical dataEvaluate protocolsEvaluate stability data and impurity identification/synthesisGuide staffGuide studentsLead studiesLead teamsManage multiple projectsManage laboratory proceduresManage research projectsManuscript preparationManuscript reviewOral presentationOrganise meetingsPlan experimentsPrepare final reportPrepare manuscriptPrepare regulatory documentsPresent data at congressproject managementPublication of articlesReport study conclusionsReport technical problemsReview dataReview data interpretationReview experimental plansReview protocolsReview reportsSet up research projectsSolve problemsSubmit regulatory applicationsTeach university studentsTeachingUnderstand protocolsUse laboratory techniquesWork with coordination and data management teamsWrite documentsWrite final reportsWrite papersWritten presentation
Ph.D. in Pharmaceutical Sciences from University of Kuopio in 2002
Master in Pharmaceutical Sciences from 1st Moscow Medical Institute in 1984
Training and Certification
Ph.D in 2002 Certification