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The general issue representing my interest is the "brain development” and the identification of altered signalling pathways that lies behind neurodevelopmental disorders of genetic origin. During my PhD (2006-2009) and my first postdoctoral stage (2010-2012), I contribute, together with a network of clinicians, to define the clinical spectrum and the genetic bases of congenital muscular dystrophies using molecular and cell biology approaches. However, during this period, my main achievement was the identification of novel epilepsy gene, TBC1D24, responsible for different forms of early-onset epilepsies and the characterization of the signalling pathway regulated by TBC1D24. I found that the modulation of ARF6, a GTPase involved into endocytosis, by TBC1D24 is crucial for neuronal maturation (Falace et al, Am J Hum Genet, 2010; Milh et al, Hum Mut, 2013). In 2013, thanks the European EPICURE network, I joined the group of Carlos Cardoso, at the Institute of Neurobiology of the Mediterranean, to complete my formation in developmental neurobiology. Indeed Cardoso’s group has a strong expertize in the development of in vivo models of Malformations of Cortical Development (MCD). In this environment, I showed that the TBC1D24/ARF6 complex regulates neuronal polarity, thus promoting neuronal migration and maturation (Falace et al, PNAS 2014). My main goal is to understand how genetic mutations impact formation and maturation of the functional cortical network and how these alterations lead to cognitive deficits and epilepsy


Current Experience

  • Post dottorato
    Since January 2013
    Our team investigates Malformations of Cortical Development (MCDs) which are important causes of mental retardation and account for 20-40% of drug-resistant childhood epilepsy. We conduct integrated multidisciplinary studies involving morphologists, molecular biologists and electrophysiologists. In addition, we have established collaborations with clinicians and geneticists (European EPICURE project) providing us with a transversal appreciation of our researches. We concentrate our efforts on: [1] the identification of new genes and molecular actors involved in normal migration processes and being altered on MCDs; [2] a better understanding of the link between genotype and phenotype, and of the process leading to an abnormal migration pattern; [3] the characterization of the physiopathological mechanisms responsible for epileptogenesis in MCDs, in order to precisely identify the seizure-generating zone, to describe its properties and the mechanisms of seizure generation, and to ultimately suggest new therapeutic approaches. - See more at:

Past Experience

  • Ricercatore post dottorato
    January 2010 --- May 2013


LinkedIn Assessment :
RicercaBiologia molecolareBiologia cellulareColtura cellulareLeadershipmanagementMiglioramento processiMicrosoft OfficePowerPointScienze naturaliPCRGenWestern blotScienzaRicerca clinicaNeuroscienzeepilessiaMalformazioni corticalisviluppo network cerebraliBiochimicaMicroscopImmunoistochimicaMicroscopia a fluorescenzaqPCRBiotecnologMicroscopio confocaleProject ManagementIn VitroIn VivoImmunofluorescenzaModelli animali


  • Diploma di Specializzazione in Genetica Medica in from Università degli Studi di Genova in 2009
  • Laurea Magistrale in Scienze Biologiche in from Università degli Studi di Genova in 2005

Area / Region

Marseille, France


Driving License
  • No