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Summary

After my MSc. in Drug Discovery and Safety with specialization in Molecular Toxicology, I am currently pursuing a PhD research in the Molecular Microbiology and Molecular Toxicology research groups at the VU University Amsterdam. This interdisciplinary PhD project is supervised by Prof. dr. Wilbert Bitter, Dr. Jan Commandeur, Dr. Daan Geerke and Dr. Dirk Bald and is part of the AIMMS STAR (Scientific Top Training in Antimicrobial Research) Programme. My research aims at novel strategies to target Mycobacterium tuberculosis drug resistance by identifying and inhibiting constitutive and stress-induced mycobacterial cytochrome P450 (P450) enzymes while avoiding off-target interaction with human P450s.

Experiences

Current Experience

  • PhD Candidate
    Since September 2015

Past Experience

  • Research intern in Clinical Pharmacy and Toxicology/Pathology
    April 2015 --- August 2015
    Phenoconversion of KRAS mutant protein in cancer cells Keywords: • Pyrosequencing • Cell culture (A431, SW480, HCT116, LoVo - cells) • Western Blotting • Cell survival (SRB, MTT- assays)

  • Research intern in Molecular and Computational Toxicology
    August 2014 --- April 2015
    Characterization of binding of drugs to cytochrome P450 (P450) enzymes and metabolism of drugs by P450s. Characterization of selected P450s from Mycobacterium tuberculosis. Key words: • Drug Metabolism • Enzyme Kinetics • Activation Energies • Isothermal Titration Calorimetry • Heterologous Expression • Protein Purification

  • Pharmacist
    April 2012 --- August 2013
    Main tasks: • Liaison with doctors and other health care professionals. • Active follow-up of drug treatment, pharmacovigilance and drug safety. • Closely monitoring the quality, safety and use of medicines. • Preparation and validation of prescriptions. • Flu-Vaccination.

  • Intern Pharmacist
    January 2011 --- July 2011
    Main tasks: • Aseptic compounding of cytotoxic chemotherapy • Medicines Information- query answering • Clinical Pharmacy- responsibility for the clinical review of a cohort of patients

Knowledge

LinkedIn Assessment :
Cell CultureEnzyme KineticsProtein ExpressionProtein PurificationMolecular CloningWestern BlottingIsothermal Titration CalorimetryHPLCCytochrome P450Molecular toxicologyDrug DiscoveryDrug Safety

Education

  • MSc in Drug Discovery and Safety from VU University Amsterdam in 2015
  • Master's Degree in Pharmacy from Universidad del País Vasco/Euskal Herriko Unibertsitatea in 2011

Area / Region

Leiden, Netherlands

Others

Driving License
  • No