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Project Manager R&D in Analytical ChemistryOctober 2012 --- May 2016
the project was about a multicompartmental metabolomics approach applied to the diagnosis of indeterminate thyroid tumours and to the Characterization of the effect of fructooligosaccharide (fos), a prebiotic, under high fat diet condition in a mouse model. the aim was to show that such approach could lead to a more global visualization of the induced metabolic modulations, and therefore, improve the identified discriminant markers relevance. regarding the diet study, the mono-compartmental Analysis of the different mouse organs/intestine segments enabled us to identify metabolic pathways affected by the high fat diet whereas the effect of fos could only be characterized for the feces samples. regarding the thyroid Cancer study, the multi-compartmental approach could not have been continued due to sample handling issues. however, the classical metabolomics Analysis of the specific samples from patients with benign or malignant tumours led to a clear discrimination between both groups with a predictivity similar to that of commercial diagnosis tests. Biomarkers were identified. in the meantime, the slow-spinning NMR hr-mas technique was explored in order to preserve the integrity of the tissues during the experiments. the use of this technique was accompanied by a number of drawbacks that i have avoided using special NMR sequences, and putting in place a robust science)" rel="nofollow">Protocol for sample preparation. finally, a filter (used in MRI) was assessed and its Applications to metabolomics as an alternative to t2 filter.
Research Assistant in Metabolomics Analysis (chemistry)January 2011 --- June 2011
classification of the men1 Gene variants the aim of the project was to help in the diagnosis of the multiple endocrine neoplasia type 1 (men 1). with our model, we classified mutations of the men1 Gene that could lead or not to Cancer by using the approach of NMR based metabolomics.
Trainee in Biology NF-kappa B and LeukaemiaJune 2007 --- June 2007
the aim was to identify and to understand the interactions of nf-kappa b with other Proteins of the signaling pathway in the leukaemia.
Doctor of Philosophy (PhD) in Analytical Chemistry from Aix Marseille University in 2016
Master's Degree 2 in Chemistry, Data Processing, Spectroscopy and Analysis from Aix Marseille University in 2013
Master's degree 2 in Pharmacology and Therapeutic Innovation from Claude Bernard Lyon 1 University in 2011
Master's degree 1, Physiopathology, Neurobiology, Pharmacology in from Nice Sophia Antipolis University in 2010