Principal scientist in Clinical Biomarker Operations
Since March 2014
• Planning and monitoring of activities for biomarker sample collection, management and logistics according to project priority and in compliance with GCP and ICH Guidelines • Review clinical trial protocols, informed consents, laboratory manuals, data transfer specifications. Support Central Laboratories for database design • Sample reconciliation and query solving in collaboration with Central Laboratories and Clinical Data Management to timely transfer sample information for clinical database lock • Support and monitoring external biobank for definition of sample management workflow, query solving, relocation and destruction • Interaction with central laboratories and Subject Matter Experts to improve sample collection, sample reconciliation and sample information transfer
Senior Scientist in Sample Management & Logistics
January 2009 --- February 2014
Management of pre-clinical and clinical samples using LIMS systems (Watson LIMS, LabWare LIMS). Pre-analytical sample processing for pharmacodynamic (PD) biomarker analysis (DNA and RNA extraction from whole blood and tissue, plasma and serum aliquot)
Scientist in Functional Genomic Lab
January 2007 --- January 2008
Implementation and validation of a High-Throughput Automated platform for Functional Genomic. Application of genomic technologies for project support: Gene expression in separated immune cell subsets from healthy volunteers and patient samples, identification of disease and PD biomarker, understanding mode of action of compounds extended to autoimmune and inflammatory diseases.
Post-doctoral scientist position
January 2005 --- January 2007
Proof of concept of contrast agent for magnetic resonance imaging to measure protein misfolding and proteolytic activity in primary neural cell culture and in vivo model of Multiple Sclerosis (Collaboration with the Chemistry Department from Turin University and the Research Center of Bracco Imaging from Ivrea). Development of assays to measure protease expression and activity in primary human cell culture and in mouse models of diseases to support projects in autoimmune and inflammatory diseases. Exploration and identification of disease and PD Biomarkers
January 2000 --- January 2005
Implementation of rat model of global cerebral ischemia and in vitro models of excitotoxicity and neuroinflammation. Development of assays to measure MMP expression and activity in rodent CNS tissue and in primary neural cell cultures to characterize the involvement of MMP activity in neuronal death, neuroinflammation and cell migration.
Ph.D in Neuroscience from Aix-Marseille University in 2005
Master in Cellular Biology and Physiology from Pierre and Marie Curie University in 2000