- extensive pre-clinical/early Clinical research experience in cardiac pharmacology and regenerative Medicine. - Pharmaceutical Industry experience in Drug Discovery spans from target identification to early Clinical Development in both Small molecules and biologic drug projects. - proven track-record of accomplishments implementing and executing R&D strategies for Drug Discovery and development. - senior role as scientific Leader for Drug Development projects in different Therapeutic Areas. - team Leader experience coordinating Lab-based Scientist to support cross-functional drug project teams. - author and co-author of multiple scientific Publications in high impact factor journals and a strong network of academic collaborators worldwide.
Associate Principal Scientist
Since March 2014
- congestive heart failure (chf) is a major cause of mortality worldwide with a steady increase in prevalence. there are multiple Treatment options at hand to slow down disease progression, but currently no available cure beyond heart transplantation. - the fundamental Pathology behind chf is a loss in functional cardiomyocytes and diminished blood flow, which are not addressed by existing standard of care. - our goal is to develop therapies for chf patients by activating endogenous regenerative processes to replace the lost myocardium. if successful, such a therapy will offer a potential cure for patients who are dying of heart failure today and an entirely new Treatment paradigm. - Congestive heart failure (CHF) is a major cause of mortality worldwide with a steady increase in prevalence. There are multiple treatment options at hand to slow down disease progression, but currently no available cure beyond heart transplantation. - The fundamental pathology behind CHF is a loss in functional cardiomyocytes and diminished blood flow, which are not addressed by existing standard of care. - Our goal is to develop therapies for CHF patients by activating endogenous regenerative processes to replace the lost myocardium. If successful, such a therapy will offer a potential cure for patients who are dying of heart failure today and an entirely new treatment paradigm.
Senior Researcher | Assistant ProfessorJanuary 2013 --- February 2014
- the role of calcium signaling in cardiac cells is pivotal, as control the contraction and relaxation of the myocardium during every heart cells beat. - in addition, calcium signaling regulates mechanisms involved in the expression and repression of multiple genes. -thus, not only the function, but also the fate of cardiac cells are geverned by calcium. - my Research line focused on the integration of calcium signaling in controlling Cell function and fate during cardiac development and regeneration.
Postdoctoral ResearcherSeptember 2009 --- December 2012
as a postdoc Scientist at karolinska intitutet, my Research was focused on investigating the role of different calcium-dependent signaling mechanisms in controlling Cell-fate determination in the context of Stem Cells differentiation, cardiomyocyte remodelling and Cancer Stem Cells activation.
Research AssistantJune 2007 --- September 2009
- during my Research period in italy, i worked with genetically-manipulated Animal models named "reporter mice". - this models allow the study of cellular processes through noninvasive, imaging-based methodologies, providing spatio-temporally insights of physiopathological events and long-term effects of xenobiotics. - my Research was focused on analyzing the activation of liver estrogen receptor in response to nutrients availability, and the role of these signals in controlling the progression of the sexual cycle and fertility.
PhD studentMarch 2003 --- May 2007
thesis title “nuclear calcium signals induced by igf-1 in cardiac myocytes: Characterization and functional mechanism” fondap centro de estudios moleculares de la célula, facultad de medicina, universidad de chile, santiago, chile. main Supervisor: sergio lavandero, phd; co-Supervisor: enrique jaimovich, phd
PharmacistJune 2002 --- December 2005
Pharmacist assistantMay 1999 --- December 1999
LinkedIn Assessment :
Postdoctoral Researcher in Cell Physiology from Karolinska institutet in 2012
Doctor of Philosophy (Ph.D.) in Biomedical Sciences from Universidad de Chile in 2010
Bachelor of Pharmacy (B.Pharm.) in Chemistry & Pharmacy from Universidad de Chile in 2000
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