Associate Principal Scientist
Since March 2014
- Congestive heart failure (CHF) is a major cause of mortality worldwide with a steady increase in prevalence. There are multiple treatment options at hand to slow down disease progression, but currently no available cure beyond heart transplantation. - The fundamental pathology behind CHF is a loss in functional cardiomyocytes and diminished blood flow, which are not addressed by existing standard of care. - Our goal is to develop therapies for CHF patients by activating endogenous regenerative processes to replace the lost myocardium. If successful, such a therapy will offer a potential cure for patients who are dying of heart failure today and an entirely new treatment paradigm.
Senior Researcher | Assistant Professor
January 2013 --- February 2014
- The role of calcium signaling in cardiac cells is pivotal, as control the contraction and relaxation of the myocardium during every heart cells beat. - In addition, calcium signaling regulates mechanisms involved in the expression and repression of multiple genes. -Thus, not only the function, but also the fate of cardiac cells are geverned by calcium. - My research line focused on the integration of calcium signaling in controlling cell function and fate during cardiac development and regeneration.
September 2009 --- December 2012
As a postdoc scientist at Karolinska Intitutet, my research was focused on investigating the role of different calcium-dependent signaling mechanisms in controlling cell-fate determination in the context of stem cells differentiation, cardiomyocyte remodelling and cancer stem cells activation.
June 2007 --- September 2009
- During my research period in Italy, I worked with genetically-manipulated animal models named "reporter mice". - This models allow the study of cellular processes through noninvasive, imaging-based methodologies, providing spatio-temporally insights of physiopathological events and long-term effects of xenobiotics. - My research was focused on analyzing the activation of liver estrogen receptor in response to nutrients availability, and the role of these signals in controlling the progression of the sexual cycle and fertility.
March 2003 --- May 2007
Thesis title “Nuclear Calcium Signals induced by IGF-1 in Cardiac Myocytes: Characterization and functional mechanism” FONDAP Centro de Estudios Moleculares de la Célula, Facultad de Medicina, Universidad de Chile, Santiago, Chile. Main supervisor: Sergio Lavandero, PhD; co-supervisor: Enrique Jaimovich, PhD
March 2004 --- December 2006
Lecturer in Pharmacology and Toxicology
March 2006 --- August 2006
Lecturer in Biophysics and Cell Physiology
June 2002 --- December 2005
March 1996 --- September 2002
Bachelor degree in Pharmaceutical Sciences Professional degree in Chemistry and Pharmacy
May 1999 --- December 1999
Postdoctoral Researcher in Cell Physiology from Karolinska institutet in 2012
Doctor of Philosophy (Ph.D.) in Biomedical Sciences from Universidad de Chile in 2010
Bachelor of Pharmacy (B.Pharm.) in Chemistry & Pharmacy from Universidad de Chile in 2000