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Summary

  • PhD in Agricultural Sciences.
  • R&D experience in: drug metabolism and pharmacokinetics (DMPK); preclinical drug development; enzyme kinetics and bioanalysis; protein purification; biological receptor assays; cell culture; modelling and simulation of biological/biochemical phenomena; .
  • Author or co-author of 16 publications in peer reviewed journals and of 23 conference posters.
  • Project management; capable of handling multiple priorities.
  • People management.
  • Analytical, organizational and problem solving skills; result-oriented.

Experiences

Past Experience

  • Principal Scientist (latest job title - DMPK (drug metabolism and pharmacokinetics) Department Beerse, België
    December 1992 --- September 2010

    Ended due to a global reorganisation

    Responsibilities:

    • Study director or principal investigator for in vitro/in vivo preclinical ADME (absorption, distribution, metabolism, excretion) and mechanistic toxicology studies; study monitor for outsourced studies; familiar with OECD Guidelines of GLP.
    • Membership/leadership in drug project and cross-functional teams (centre of expertise on drug-drug interactions, in vitro–in vivo extrapolation and enzyme reaction phenotyping; study outsourcing).
    • Project management: DMPK representative of allocated projects.
    • Scientific input: optimization of existing procedures and implementation of novel assays (including automation of enzyme assays); scientific lectures; consultation on technical/scientific issues to colleague study directors and team members; scientific support of dossiers at the occasion of questions from regulatory
    • Scientific writing: author and reviewer of preclinical protocols, study reports and technical notes.
    • People management: coaching/ leadership of new study directors, students and lab technicians.
    • Liaise with external collaborators (J&J US) and researchers at CROs and academic institutions.

    Accomplishments:

    • Supervision of about 270 preclinical DMPK studies.
    • Appropriate contributions for registration of new human (CNS, HIV, oncology, infection, Hep C, GI, Alzheimer) and veterinary (obesity in dog) drugs and for re-registration of a postharvest fungicide.
    • Johnson & Johnson Standards of Leadership Award for partnership on the submission of a new oncology drug.
    • Peer-reviewed publications; poster presentations at scientific symposia.

  • Research Assistant (Department of Veterinary Physiology) Ghent, België
    August 1990 --- December 1991

    Responsibilities:

    • Development and validation of a radio-ligand beta2-adrenoceptor binding assay with low aspecific binding, suitable to assess the milk-ability of dairy cows.

    Accomplishments:

    • Peer-reviewed publication

  • Research Assistant (Department of Agro-Engineering) Leuven, België
    June 1989 --- July 1990

    Responsibilities:

    • Supervision of a research project aimed at the development of an on-line system in the milking machine to detect subclinical mastitis in dairy cows.

    Accomplishments:

    • Inventory of subclinical mastitis indicators in milk. Evaluation of the predictive value of selected physiological and biochemical parameters.

  • Research Assistant (Department of Medical Research) Leuven, België
    October 1981 --- July 1988

    Responsibilities:

    • Development and validation of a radio-assay to study hepatic bilirubin metabolism.
    • Evaluation of mathematical models for kinetic and binding equilibria of lipophilic substrates and ligands with membrane-bound enzymes and acceptors, in which linear solute partition in the membrane is taken into account.

    Accomplishments:

    • PhD thesis.
    • Peer-reviewed publications.

  • Trainee (Rega Institute for Medical Research) Leuven, België
    March 1981 --- June 1981

    Responsibilities:

    • Hybridoma culture and screening for anti-interferon-gamma monoclonal antibodies.

Personality

Self Assessment :
Analytical thinkingOptimismProblem solvingInterest in knowledgeInnovative thinkingEfficiencyCuriosityCritical thinkingCollaborationAttention to detailProactivity

Knowledge

Self Assessment :
R&D Scientific writingData AnalysisDrug development processDrug InteractionDrug metabolismEarly development stageEnglishGenetic polymorphismGood Laboratory Practice (GLP)HPLCIn VitroIn VivoIt skillsKnowledge of the drug development processLaboratoryLaboratory study designPharmacokineticsPowerPointPre-clinical researchProcess improvementProblem-solving methods and troubleshootingPreclinical regulations and practicesPosition PaperProtocolR&DRate of drug eliminationSDS-PAGEScientific methodologySOPTeam LeadershipToxicology

Skills and Expertise

Self Assessment :
Present data at congressPublication of articlesReview study protocolsShipment of biological specimenSolve problems Analyze data Create SOPs Develop protocols Control data Guide students Interpret data Report data Write papersAttend seminarsAdjust methodsAnalyze dataCoachCollaborate with project teamConduct literature searchesConduct research at universitiesDesign studyDirect co-workersEvaluate protocolsExecute scientific projectsInteract with CROsInteract with pre-clinical scientistsManuscript preparation and reviewNegotiate protocol details Oral presentationOrganise meetingsPrepare final report

Education

  • Ph.D. in Agricultural Sciences from Catholic University of Leuven in 1992
  • Agricultural Engineer in Agricultural Sciences from Catholic University of Leuven in 1980

Training and Certification

  • Hands-on Toxicology in 2011 Certification
  • Population-based in vitro-in vivo extrapolation of ADME properties in 2008 Certification
  • Design of experiments in chemical and related industries in 2007 Certification
  • Interpretation of MS/MS spectra in 2004 Certification
  • Molecular Biological Techniques in 2002 Certification
  • Pharmacokinetics in 2001 Certification

Languages

BrightOwl Assessment:
Self Assessment:
English
Full Proficiency
French
Professional Proficiency
German
Elementary Proficiency
Dutch
Native

Work Preferences

  • Positions I am interested in:
    Project Manager Managing Director Research Scientist Scientist researcher Senior Project Manager (PM)
  • Work From Home:
    Yes, 0 to 2 days per week
  • Work Regime:
    Permanent position :    100 % FTE
  • International:
    Yes

Publications

    Expert has 16 publications (Will be avalible with full profile)

Area / Region

Zele, België

Others

Driving License
  • Yes