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Current Experience

  • Scientific Advisor Regulatory Affairs

    Brussels, Belgium
    Since December 2015


    • monitor of studies (physicochemistry, Analytical Method Validation, residues, Metabolism, operator exposure) for registration of plant protection products; scientific advise
    • writing of scientific summaries and making risk assessments according to eu guidelines
    • Project Management


    • Monitor of studies (physicochemistry, analytical method validation, residues, metabolism, operator exposure) for registration of plant protection products; scientific advise
    • Writing of scientific summaries and making risk assessments according to EU guidelines
    • Project management

Past Experience

  • Principal Scientist (latest job title - DMPK (drug metabolism and pharmacokinetics) Department Beerse, België

    December 1992 --- September 2010

    ended due to a global reorganisation


    • study Director or principal Investigator for in vitro/In Vivo Preclinical adme (absorption, distribution, Metabolism, excretion) and mechanistic Toxicology studies; study monitor for outsourced studies; familiar with oecd guidelines of glp.
    • membership/Leadership in drug project and cross-functional teams (centre of expertise on drug-drug interactions, In VitroIn Vivo extrapolation and Enzyme reaction phenotyping; study Outsourcing).
    • Project Management: dmpk representative of allocated projects.
    • scientific input: optimization of existing procedures and implementation of novel Assays (including Automation of Enzyme Assays); scientific lectures; consultation on technical/scientific issues to colleague study directors and team members; scientific support of dossiers at the occasion of questions from regulatory
    • Scientific writing: author and Reviewer of Preclinical protocols, study reports and technical notes.
    • people management: Coaching/ Leadership of new study directors, students and Lab technicians.
    • liaise with external collaborators (j&j us) and researchers at cros and academic institutions.


    • supervision of about 270 Preclinical dmpk studies.
    • appropriate contributions for registration of new human (CNS, hiv, oncology, infection, hep c, gi, alzheimer) and Veterinary (obesity in dog) drugs and for re-registration of a postharvest fungicide.
    • johnson & johnson standards of Leadership award for partnership on the submission of a new oncology drug.
    • peer-reviewed Publications; poster Presentations at scientific symposia.

  • Research Assistant (Department of Veterinary Physiology) Ghent, België

    August 1990 --- December 1991


    • development and Validation of a radio-ligand beta2-adrenoceptor binding assay with low aspecific binding, suitable to assess the milk-ability of dairy cows.


    • peer-reviewed publication

  • Research Assistant (Department of Agro-Engineering) Leuven, België

    June 1989 --- July 1990


    • supervision of a Research project aimed at the development of an on-line system in the milking machine to detect subclinical mastitis in dairy cows.


    • inventory of subclinical mastitis indicators in milk. evaluation of the predictive value of selected physiological and biochemical parameters.

  • Research Assistant (Department of Medical Research) Leuven, België

    October 1981 --- July 1988


    • development and Validation of a radio-assay to study hepatic bilirubin Metabolism.
    • evaluation of mathematical models for kinetic and binding equilibria of lipophilic substrates and ligands with membrane-bound enzymes and acceptors, in which linear solute partition in the membrane is taken into account.


  • Trainee (Rega Institute for Medical Research) Leuven, België

    March 1981 --- June 1981



Self Assessment :
Analytical thinkingOptimismProblem solvingInterest in knowledgeInnovative thinkingEfficiencyCuriosityCritical thinkingCollaborationAttention to detailProactivity


Self Assessment :
R&D Scientific writingData AnalysisDrug development processDrug InteractionDrug metabolismEarly development stageEnglishGenetic polymorphismGood Laboratory Practice (GLP)HPLCIn VitroIn VivoIt skillsKnowledge of the drug development processLaboratoryLaboratory study designPharmacokineticsPowerPointPre-clinical researchProcess improvementProblem-solving methods and troubleshootingPreclinical regulations and practicesPosition PaperProtocolR&DRate of drug eliminationSDS-PAGEScientific methodologySOPTeam LeadershipToxicology

Skills and Expertise

Self Assessment :
Present data at congressPublication of articlesReview study protocolsShipment of biological specimenSolve problems Analyze data Create SOPs Develop protocols Control data Guide students Interpret data Report data Write papersAttend seminarsAdjust methodsAnalyze dataCoachCollaborate with project teamConduct literature searchesConduct research at universitiesDesign studyDirect co-workersEvaluate protocolsExecute scientific projectsInteract with CROsInteract with pre-clinical scientistsManuscript preparation and reviewNegotiate protocol details Oral presentationOrganise meetingsPrepare final report


  • Ph.D. in Agricultural Sciences from Catholic University of Leuven in 1992
  • Agricultural Engineer in Agricultural Sciences from Catholic University of Leuven in 1980

Training and Certification

  • Hands-on Toxicology in 2011 Certification
  • Population-based in vitro-in vivo extrapolation of ADME properties in 2008 Certification
  • Design of experiments in chemical and related industries in 2007 Certification
  • Interpretation of MS/MS spectra in 2004 Certification
  • Molecular Biological Techniques in 2002 Certification
  • Pharmacokinetics in 2001 Certification


BrightOwl Assessment:
Self Assessment:
Full Proficiency
Professional Proficiency
Elementary Proficiency

Work Preferences

  • Positions I am interested in:
    Project Manager Managing Director Research Scientist Scientist researcher Senior Project Manager (PM)
  • Work From Home:
    Yes, 0 to 2 days per week
  • Work Regime:
    Permanent position :    100 % FTE
  • International:


    Expert has 16 publications (Will be avalible with full profile)

Area / Region

Zele, België


Driving License
  • Yes

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